Aliases:This biomarker is also known as:
- signal transducer and activator of transcription 6,
- IL-4 Stat,
- STAT, interleukin4-induced,
- signal transducer and activator of transcription 6, interleukin-4 induced,
- transcription factor IL-4 STAT,
STAT6 is a member of the STAT family of transcription factors. STAT family members are phosphorylated by the receptor associated kinases in response to cytokines and growth factors and are involved in signal transduction and activation of transcription. There are several transcript variants produced by alternative splicing.
There are no datasets associated with this biomarker.
The following organs have data associated with this biomarker…
|QA State:||Under Review|
The transcription factor STAT6 is a member of a family of DNA binding proteins. STAT6 has been shown to be a critical cell differentiation modulator in breast cancer cells.
STAT6 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.
- Plasma biomarker profiles differ depending on breast cancer subtype but RANTES is consistently increased.
- Stat6 cooperates with Sp1 in controlling breast cancer cell proliferation by modulating the expression of p21(Cip1/WAF1) and p27 (Kip1).
- Discovery and preliminary confirmation of novel early detection biomarkers for triple-negative breast cancer using preclinical plasma samples from the Women's Health Initiative observational study.
|UniProt Accession #:||P42226|
|Mutated Sites Count:||196|
|Associated Pubmed ID Count||17|
|Affected Protein Function Sites Count:||5|