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ST14

Basics

Aliases:
This biomarker is also known as:
  • MTSP1,
  • Q9Y5Y6,
  • EC 3.4.21.109,
  • SNC19,
  • PRSS14,
  • EC 3.4.21,
  • tumor associated differentially expressed gene 15 protein,
  • prostamin,
  • OTTHUMP00000230932,
  • suppressor of tumorigenicity 14 protein,
  • Matriptase,
  • Serine protease TADG-15,
  • Tumor-associated differentially-expressed gene 15 protein,
  • Membrane-type serine protease 1,
  • OTTHUMP00000230931,
  • HAI,
  • TADG15,
  • suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin),
  • MT-SP1,
  • Prostamin,
  • Serine protease 14,
  • suppression of tumorigenicity 14 (colon carcinoma),
  • TMPRSS14,

Description…

ST14 protein is an epithelial-derived, integral membrane serine protease and is found to be activated by sphingosine 1-phosphate. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis.

Attributes

QA State: Curated
Type: Protein
Short Name:
HGNC Name: ST14

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Ovary

Attributes

Phase: Two
QA State: Under Review

Overview

ST14 localized to vascular-like structures in ovarian cancer but not in normal ovaries.

Performance Comment

ST14 was one of 13 genes out of 50 selected for further validation in PMID:21617380. Average expression of ST14 was significantly higher in epithelial ovarian cancer tumors than any other normal tissue tested.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Biomuta

Mutation Statistics

Gene Name: ST14
UniProt Accession #: Q9Y5Y6
Mutated Sites Count: 127
Associated Pubmed ID Count 24
CancerDO Count 26
Affected Protein Function Sites Count: 5

View in BioMuta