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This biomarker is also known as:
  • Serine protease TADG-15,
  • TADG15,
  • OTTHUMP00000230931,
  • MTSP1,
  • PRSS14,
  • suppression of tumorigenicity 14 (colon carcinoma),
  • suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin),
  • TMPRSS14,
  • Tumor-associated differentially-expressed gene 15 protein,
  • SNC19,
  • prostamin,
  • HAI,
  • EC,
  • Membrane-type serine protease 1,
  • OTTHUMP00000230932,
  • suppressor of tumorigenicity 14 protein,
  • EC 3.4.21,
  • Prostamin,
  • Q9Y5Y6,
  • Serine protease 14,
  • tumor associated differentially expressed gene 15 protein,
  • Matriptase,
  • MT-SP1,

View in BioMuta


ST14 protein is an epithelial-derived, integral membrane serine protease and is found to be activated by sphingosine 1-phosphate. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis.


QA State: Curated
Type: Protein
Short Name:
HGNC Name: ST14


There are no datasets associated with this biomarker.


The following organs have data associated with this biomarker…



Phase: Two
QA State: Under Review


ST14 localized to vascular-like structures in ovarian cancer but not in normal ovaries.

Performance Comment

ST14 was one of 13 genes out of 50 selected for further validation in PMID:21617380. Average expression of ST14 was significantly higher in epithelial ovarian cancer tumors than any other normal tissue tested.


This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at if you should have access to this biomarker.

2015 Steering Committee Meeting

The next EDRN Steering Committee Meeting will take place March 31st through April 2nd, 2015, in Atlanta, Georgia.

Announcement 02/12/2015

Please register for the 29th EDRN Steering Committee Meeting in Atlanta, GA from March 31-April 2, 2015. The registration page has information about booking hotel rooms and a draft agenda of the meeting.