Aliases:This biomarker is also known as:
- spondin 2,
- spondin 2, extracellular matrix protein,
- Differentially expressed in cancerous and non-cancerous lung cells 1,
SPON2, also known as spondin-2, is a cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. It binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Spondin-2 is essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the extacellular matrix for microbial pathogens. Spondin-2 also binds bacterial lipopolysaccharide.
There are no datasets associated with this biomarker.
The following organs have data associated with this biomarker…
Spondin-2 has been identified as potential ovarian cancer biomarkers. In a 2007 study (Simon, I. Gynecol Oncol. 2007 Jul;106(1):112-8. Epub 2007 May 8) Spondin 2, B7-H4, and DcR3 were evaluated for their ability to identify clinical disease. The three novel markers and CA125 were elevated in serum of ovarian cancer patients as compared to normal controls.
Of the 28 ovarian cancer biomarkers tested in prediagnostic specimens, from the PLCO, CA125 remains the single best biomarker for ovarian cancer and has its strongest signal within six months of diagnosis. SPON2 alone was not a strong predictor.
No associated publications found.
- HGNC entry for SPON2 from Genenames
- KEGG entry for SPON2 from Genome.jp
- Entrez entry for SPON2 all NCBI Databasese
- Human GEO Profiles for SPON2 from NCBI GEO Profiles
- Human Geo Datasets containing term SPON2 from NCBI GEO Datasets
- GWAS Study Datasets containing gene SPON2 from GWAS
- Human Single Nucleotide Polymorphisms info for SPON2
- Human Gene(s) with 'SPON2' as Gene Name/Alias
- Human Gene RefSeq for SPON2 from NCBI
- GeneCards entry for human SPON2
- UniProtKB/Swiss-Prot entry for SPON2 from Uniprot
- Human Protein RefSeq for SPON2 from NCBI
- FDA web page describing approval of SPON2
No other associated resources found.
|UniProt Accession #:||Q9BUD6|
|Mutated Sites Count:||44|
|Associated Pubmed ID Count||9|
|Affected Protein Function Sites Count:||4|