Aliases:This biomarker is also known as:
- natural resistance-associated macrophage protein 1,
- solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1,
- NRAMP 1,
- solute carrier family 11 (sodium/phosphate symporters), member 1,
SLC11A1 is a membrane associated divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. SLC11A1 is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family. Mutations in the SLC11A1 gene are involved in susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn disease. Several alternatively spliced variants have been identified.
There are no datasets associated with this biomarker.
The following organs have data associated with this biomarker…
|QA State:||Under Review|
NRAMP expression was absent in HUVEC (human umbilical vein endothelial cells) and tumor endothelial cells, but expression was detected in tumor leukocytes as well as normal monocytes.
SLC11A1 (NRAMP) was one of 13 genes out of 50 selected for further validation in PMID:21617380.
|UniProt Accession #:||P49279|
|Mutated Sites Count:||79|
|Associated Pubmed ID Count||12|
|Affected Protein Function Sites Count:||4|