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SLAMF8

Basics

Aliases:
This biomarker is also known as:
  • BCM-like membrane protein,
  • SLAM family member 8,
  • SBBI42,
  • CD353,
  • BLAME,
  • Q9P0V8,
  • B-lymphocyte activator macrophage expressed,
  • CD353 antigen,
  • B lymphocyte activator macrophage expressed,

Description…

SLAMF8 is a membrane protein belonging to the CD2 family of cell surface proteins. This protein family is characterized by Ig domains. SLAMF8 is expressed in lymph node, spleen, thymus and bone marrow. SLAMF8 may play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor. There are two isoforms of this protein, produced by alternative splicing.

Attributes

QA State: Curated
Type: Protein
Short Name:
HGNC Name: SLAMF8

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Ovary

Attributes

Phase: Two
QA State: Under Review

Overview

BLAME expression was absent in HUVEC (human umbilical vein endothelial cells) and tumor endothelial cells, but expression was detected in tumor leukocytes as well as normal monocytes.

Performance Comment

SLAMF8 (BLAME) was one of 13 genes out of 50 selected for further validation in PMID:21617380. SLAMF8 (BLAME) shows its highest levels of expression in tonsil and lung tissue and therefore could be suitable for abdominal imaging.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Biomuta

Mutation Statistics

Gene Name: SLAMF8
UniProt Accession #: Q9P0V8
Mutated Sites Count: 57
Associated Pubmed ID Count 5
CancerDO Count 21
Affected Protein Function Sites Count: 1

View in BioMuta

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