Aliases:This biomarker is also known as:
- ubiquitin C,
- Ubiquitin carboxyl extension protein 80,
- ubiquitin carboxyl extension protein 80,
- 40S ribosomal protein S27a,
- ubiquitin and ribosomal protein S27a,
- ribosomal protein S27a,
- ubiquitin-40S ribosomal protein S27a,
Ubiquitin, one of the most highly conserved proteins, is coded for by a family of genes whose translation products give rise to several different proteins. There are four genes that code for ubiquitin: UBB, UBC, RPS27A, and UBA52. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. UBA52 and RPS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains. This gene, RPS27A, encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein S27a at the C terminus. When expressed in yeast, the protein is post-translationally processed, generating free ubiquitin monomer and ribosomal protein S27a. Ribosomal protein S27a is a component of the 40S subunit of the ribosome and belongs to the S27AE family of ribosomal proteins. Multiple alternatively spliced transcript variants that encode the same proteins have been identified.
|QA State:||Under Review|
There are no datasets associated with this biomarker.