Aliases:This biomarker is also known as:
- retinoic acid receptor beta 2,
- retinoic acid receptor beta variant 2,
- hepatitis B virus activated protein,
- retinoic acid receptor beta 4,
- retinoic acid receptor beta variant 1,
- Nuclear receptor subfamily 1 group B member 2,
- retinoic acid receptor beta 5,
- retinoic acid receptor beta,
- retinoic acid receptor, beta polypeptide,
- retinoic acid receptor, beta,
- HBV-activated protein,
The RARB gene encodes the retinoic acid receptor beta. It is a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators (NRB1 class). These receptors bind to their targets as heterodimers in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. This receptor localizes to the cytoplasm and to subnuclear compartments where it binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that the RARB protein limits growth of many cell types by regulating gene expression. There are three distinct RAR subtypes; RARalpha, RARbeta and RARgamma. RARalpha is present in most tissue types, whereas RARbeta and RARgamma expression is more selective. Two full length transcript variants have been verified. A third is possible.
|QA State:||Under Review|
There are no datasets associated with this biomarker.