RAB13

Basics

Aliases:

This biomarker is also known as:

RAS-associated protein RAB13,
growth-inhibiting gene 4 protein,
cell growth-inhibiting gene 4 protein,
ras-related protein Rab-13,
RAB13, member RAS oncogene family,
Cell growth-inhibiting gene 4 protein,

Description…

RAB13 is a member of the Rab family of small G proteins and plays a role in regulating membrane trafficking between trans-Golgi network (TGN) and recycling endosomes (RE). RAB13 is thought to participate in polarized transport, in the assembly and/or the activity of tight junctions, which are components of the apical junctional complex (AJC) of epithelial cells. There are several alternatively spliced transcript variants for this gene, and a pseudogene located on chromosome 12.

Attributes

QA State:	Curated
Type:	Protein
Short Name:
HGNC Name:	RAB13

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Breast

Attributes

Phase:	Two
QA State:	Under Review

Overview

No additional breast data available.

Performance Comment

RAB13 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Publications

Resources

External Resources for RAB13

This gene is a member of the Rab family of small G proteins and plays a role in regulating membrane trafficking between trans-Golgi network (TGN) and recycling endosomes (RE). The encoded protein is involved in the assembly of tight junctions, which are components of the apical junctional complex (AJC) of epithelial cells. The AJC plays a role in forming a barrier between luminal contents and the underlying tissue. Additional functions associated with the protein include endocytic recycling of occludin, regulation of epithelial cell scattering, neuronal regeneration and regulation of neurite outgrowth. Alternately spliced transcript variants have been observed for this gene. A pseudogene associated with this gene is located on chromosome 12.

RAB13 is part of the pathway: Tight junction - Homo sapiens (human)