RAB13
Basics
Aliases:
This biomarker is also known as:- Cell growth-inhibiting gene 4 protein,
- ras-related protein Rab-13,
- RAB13, member RAS oncogene family,
- RAS-associated protein RAB13,
- growth-inhibiting gene 4 protein,
- cell growth-inhibiting gene 4 protein,
Description…
RAB13 is a member of the Rab family of small G proteins and plays a role in regulating membrane trafficking between trans-Golgi network (TGN) and recycling endosomes (RE). RAB13 is thought to participate in polarized transport, in the assembly and/or the activity of tight junctions, which are components of the apical junctional complex (AJC) of epithelial cells. There are several alternatively spliced transcript variants for this gene, and a pseudogene located on chromosome 12.
Attributes
| QA State: | Curated |
|---|---|
| Type: | Protein |
| Short Name: | |
| HGNC Name: | RAB13 |
Datasets
There are no datasets associated with this biomarker.
Organs
The following organs have data associated with this biomarker…
Breast
Attributes
| Phase: | Two |
|---|---|
| QA State: | Under Review |
Overview
No additional breast data available.
Performance Comment
RAB13 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.
Studies
This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.
Publications
- Discovery and preliminary confirmation of novel early detection biomarkers for triple-negative breast cancer using preclinical plasma samples from the Women's Health Initiative observational study.
- Plasma biomarker profiles differ depending on breast cancer subtype but RANTES is consistently increased.
Resources
Gene
- HGNC entry for RAB13 from Genenames
- KEGG entry for RAB13 from Genome.jp
- Entrez entry for RAB13 all NCBI Databasese
- Human GEO Profiles for RAB13 from NCBI GEO Profiles
- Human Geo Datasets containing term RAB13 from NCBI GEO Datasets
- GWAS Study Datasets containing gene RAB13 from GWAS
- Human Single Nucleotide Polymorphisms info for RAB13
- Human Gene(s) with 'RAB13' as Gene Name/Alias
- Human Gene RefSeq for RAB13 from NCBI
- GeneCards entry for human RAB13
Protein
- UniProtKB/Swiss-Prot entry for RAB13 from Uniprot
- Human Protein RefSeq for RAB13 from NCBI
- FDA web page describing approval of RAB13
Other
Biomuta
Mutation Statistics
| Gene Name: | RAB13 |
|---|---|
| UniProt Accession #: | P51153 |
| Mutated Sites Count: | 37 |
| Associated Pubmed ID Count | 1 |
| CancerDO Count | 15 |
| Affected Protein Function Sites Count: | 4 |
