RAB13
Basics
Aliases:
This biomarker is also known as:- cell growth-inhibiting gene 4 protein,
- RAS-associated protein RAB13,
- ras-related protein Rab-13,
- growth-inhibiting gene 4 protein,
- RAB13, member RAS oncogene family,
- Cell growth-inhibiting gene 4 protein,
Description…
RAB13 is a member of the Rab family of small G proteins and plays a role in regulating membrane trafficking between trans-Golgi network (TGN) and recycling endosomes (RE). RAB13 is thought to participate in polarized transport, in the assembly and/or the activity of tight junctions, which are components of the apical junctional complex (AJC) of epithelial cells. There are several alternatively spliced transcript variants for this gene, and a pseudogene located on chromosome 12.
Attributes
| QA State: | Curated |
|---|---|
| Type: | Protein |
| Short Name: | |
| HGNC Name: | RAB13 |
Datasets
There are no datasets associated with this biomarker.
Organs
The following organs have data associated with this biomarker…
Breast
Attributes
| Phase: | Two |
|---|---|
| QA State: | Under Review |
Overview
No additional breast data available.
Performance Comment
RAB13 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.
Studies
This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.
Publications
- Prognostic significance of occult tumor cells in the apheresis products of patients with advanced breast cancer receiving high-dose chemotherapy and autologous hematopoietic progenitor cell support.
- Longitudinal assessment of urinary PCA3 for predicting prostate cancer grade reclassification in favorable-risk men during active surveillance.
Resources
External Resources for RAB13
Gene
- HGNC entry for RAB13 from Genenames
- KEGG entry for RAB13 from Genome.jp
- Ensembl entry for RAB13
- Entrez entry for RAB13 all NCBI Databasese
- GWAS Study Datasets containing gene RAB13 from GWAS
- Find Human Single Nucleotide Polymorphisms info for RAB13
- Human Gene(s) with 'RAB13' as Gene Name/Alias
- Human RNA sequence for 'RAB13'
- GeneCards entry for human RAB13
Protein
- UniProtKB/Swiss-Prot entry for RAB13 from Uniprot
- Human Protein RefSeq for RAB13 from NCBI
- Pfam: Protein family information for RAB13
Other
No other associated resources found.
Biomuta
Mutation Statistics
| Gene Name: | RAB13 |
|---|---|
| UniProt Accession #: | P51153 |
| Mutated Sites Count: | 31 |
| Associated Pubmed ID Count | 1 |
| CancerDO Count | 12 |
| Affected Protein Function Sites Count: | 2 |
