RAB13
Basics
Aliases:
This biomarker is also known as:- RAS-associated protein RAB13,
- cell growth-inhibiting gene 4 protein,
- growth-inhibiting gene 4 protein,
- Cell growth-inhibiting gene 4 protein,
- RAB13, member RAS oncogene family,
- ras-related protein Rab-13,
Description…
RAB13 is a member of the Rab family of small G proteins and plays a role in regulating membrane trafficking between trans-Golgi network (TGN) and recycling endosomes (RE). RAB13 is thought to participate in polarized transport, in the assembly and/or the activity of tight junctions, which are components of the apical junctional complex (AJC) of epithelial cells. There are several alternatively spliced transcript variants for this gene, and a pseudogene located on chromosome 12.
Attributes
| QA State: | Curated |
|---|---|
| Type: | Protein |
| Short Name: | |
| HGNC Name: | RAB13 |
Datasets
There are no datasets associated with this biomarker.
Organs
The following organs have data associated with this biomarker…
Breast
Attributes
| Phase: | Two |
|---|---|
| QA State: | Under Review |
Overview
No additional breast data available.
Performance Comment
RAB13 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.
Studies
This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.
Publications
- Discovery and preliminary confirmation of novel early detection biomarkers for triple-negative breast cancer using preclinical plasma samples from the Women's Health Initiative observational study.
- Plasma biomarker profiles differ depending on breast cancer subtype but RANTES is consistently increased.
Resources
External Resources for RAB13
Gene
Protein
Other
Biomuta
Mutation Statistics
| Gene Name: | RAB13 |
|---|---|
| UniProt Accession #: | P51153 |
| Mutated Sites Count: | 37 |
| Associated Pubmed ID Count | 1 |
| CancerDO Count | 15 |
| Affected Protein Function Sites Count: | 4 |
