Aliases:This biomarker is also known as:
- protein tyrosine phosphatase, receptor type, E,
- protein tyrosine phosphatase, receptor type, epsilon polypeptide,
- receptor-type tyrosine-protein phosphatase epsilon,
- EC 18.104.22.168,
- Protein-tyrosine phosphatase epsilon,
PTPRE is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. The PTPRE gene encodes two isoforms, one of which is a receptor-type PTP, and the other which is not a receptor-type PTP. Both isoforms act as negative regulators of FceRI-mediated signal transduction leading to cytokine production and degranulation.
There are no datasets associated with this biomarker.
The following organs have data associated with this biomarker…
|QA State:||Under Review|
No additional breast data available.
PTPRE was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.
- Discovery and preliminary confirmation of novel early detection biomarkers for triple-negative breast cancer using preclinical plasma samples from the Women's Health Initiative observational study.
- Plasma biomarker profiles differ depending on breast cancer subtype but RANTES is consistently increased.
- HGNC entry for PTPRE from Genenames
- KEGG entry for PTPRE from Genome.jp
- Entrez entry for PTPRE all NCBI Databasese
- Human GEO Profiles for PTPRE from NCBI GEO Profiles
- Human Geo Datasets containing term PTPRE from NCBI GEO Datasets
- GWAS Study Datasets containing gene PTPRE from GWAS
- Human Single Nucleotide Polymorphisms info for PTPRE
- Human Gene(s) with 'PTPRE' as Gene Name/Alias
- Human Gene RefSeq for PTPRE from NCBI
- GeneCards entry for human PTPRE
- UniProtKB/Swiss-Prot entry for PTPRE from Uniprot
- Human Protein RefSeq for PTPRE from NCBI
- FDA web page describing approval of PTPRE
|UniProt Accession #:||P23469|
|Mutated Sites Count:||217|
|Associated Pubmed ID Count||13|
|Affected Protein Function Sites Count:||5|