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PTPRE

Basics

Aliases:
This biomarker is also known as:
  • R-PTP-EPSILON,
  • protein tyrosine phosphatase, receptor type, epsilon polypeptide,
  • HPTPE,
  • R-PTP-epsilon,
  • receptor-type tyrosine-protein phosphatase epsilon,
  • EC 3.1.3.48,
  • protein tyrosine phosphatase, receptor type, E,
  • PTPE,
  • Protein-tyrosine phosphatase epsilon,

Description…

PTPRE is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. The PTPRE gene encodes two isoforms, one of which is a receptor-type PTP, and the other which is not a receptor-type PTP. Both isoforms act as negative regulators of FceRI-mediated signal transduction leading to cytokine production and degranulation.

Attributes

QA State: Curated
Type: Protein
Short Name:
HGNC Name: PTPRE

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Breast

Attributes

Phase: Two
QA State: Under Review

Overview

No additional breast data available.

Performance Comment

PTPRE was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Resources

External Resources for PTPRE

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Several alternatively spliced transcript variants of this gene have been reported, at least two of which encode a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokine-induced SATA signaling, as well as the activation of voltage-gated K+ channels.

Gene

Protein

Other

No other associated resources found.

Biomuta

Mutation Statistics

Gene Name: PTPRE
UniProt Accession #: P23469
Mutated Sites Count: 215
Associated Pubmed ID Count 12
CancerDO Count 24
Affected Protein Function Sites Count: 5

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