PTPN11
Basics
Aliases:
This biomarker is also known as:- BPTP3,
- PTP-1D,
- PTP2C,
- EC 3.1.3.48,
- SH-PTP2,
- protein-tyrosine phosphatase 1D,
- protein tyrosine phosphatase, non-receptor type 11,
- protein-tyrosine phosphatase 2C,
- SHPTP2,
- Shp2,
- SH-PTP3,
- Protein-tyrosine phosphatase 2C,
- SHP2,
- tyrosine-protein phosphatase non-receptor type 11,
- NS1,
- SHP-2,
- CFC,
- PTP-2C,
- Protein-tyrosine phosphatase 1D,
- Noonan syndrome 1,
Description…
PTPN11 is a member of the protein tyrosine phosphatase (PTP) family. PTP family members are a group of enzymes that catalyze the removal of phosphate groups from tyrosine residues by the hydrolysis of phosphoric acid monoesters. The activity of PTPs opposite that of kinases and phosphorylases and therefore PTPs play an integral role in many signal transduction pathways. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPN11 is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration.
Attributes
QA State: | Curated |
---|---|
Type: | Protein |
Short Name: | |
HGNC Name: | PTPN11 |
Datasets
There are no datasets associated with this biomarker.
Organs
The following organs have data associated with this biomarker…
Breast
Attributes
Phase: | Two |
---|---|
QA State: | Under Review |
Overview
No additional breast data available.
Performance Comment
PTPN11 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.
Studies
This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.
Publications
- Longitudinal assessment of urinary PCA3 for predicting prostate cancer grade reclassification in favorable-risk men during active surveillance.
- Prognostic significance of occult tumor cells in the apheresis products of patients with advanced breast cancer receiving high-dose chemotherapy and autologous hematopoietic progenitor cell support.
Resources
External Resources for PTPN11
Gene
- Entrez entry for PTPN11 all NCBI Databasese
- Find Human Single Nucleotide Polymorphisms info for PTPN11
- Human Gene(s) with 'PTPN11' as Gene Name/Alias
- GeneCards entry for human PTPN11
Protein
Other
No other associated resources found.
Biomuta
Mutation Statistics
Gene Name: | PTPN11 |
---|---|
UniProt Accession #: | Q06124 |
Mutated Sites Count: | 126 |
Associated Pubmed ID Count | 46 |
CancerDO Count | 25 |
Affected Protein Function Sites Count: | 3 |