You are here: Home / Biomarkers / PTPN11



This biomarker is also known as:
  • SH-PTP2,
  • PTP-2C,
  • SHP2,
  • Noonan syndrome 1,
  • EC,
  • SHPTP2,
  • tyrosine-protein phosphatase non-receptor type 11,
  • protein tyrosine phosphatase, non-receptor type 11,
  • Protein-tyrosine phosphatase 2C,
  • Protein-tyrosine phosphatase 1D,
  • NS1,
  • Shp2,
  • protein-tyrosine phosphatase 2C,
  • BPTP3,
  • protein-tyrosine phosphatase 1D,
  • PTP2C,
  • SH-PTP3,
  • SHP-2,
  • PTP-1D,
  • CFC,


PTPN11 is a member of the protein tyrosine phosphatase (PTP) family. PTP family members are a group of enzymes that catalyze the removal of phosphate groups from tyrosine residues by the hydrolysis of phosphoric acid monoesters. The activity of PTPs opposite that of kinases and phosphorylases and therefore PTPs play an integral role in many signal transduction pathways. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPN11 is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration.


QA State: Curated
Type: Protein
Short Name:


There are no datasets associated with this biomarker.


The following organs have data associated with this biomarker…



Phase: Two
QA State: Under Review


No additional breast data available.

Performance Comment

PTPN11 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.


This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at if you should have access to this biomarker.


Mutation Statistics

Gene Name: PTPN11
UniProt Accession #: Q06124
Mutated Sites Count: 126
Associated Pubmed ID Count 46
CancerDO Count 25
Affected Protein Function Sites Count: 3

View in BioMuta

This icon signifies that something is happening and we kindly ask you to please wait