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PTPMT1

Basics

Aliases:
This biomarker is also known as:
  • Phosphoinositide lipid phosphatase,
  • protein tyrosine phosphatase, mitochondrial 1,
  • protein-tyrosine phosphatase mitochondrial 1,
  • EC 3.1.3.16,EC 3.1.3.48,
  • PTEN-like phosphatase,
  • phosphoinositide lipid phosphatase,
  • MOSP,
  • DUSP23,
  • PLIP,
  • NB4 apoptosis/differentiation related protein,

Description…

PTPMT1 is a lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle.

Attributes

QA State: Curated
Type: Protein
Short Name:
HGNC Name: PTPMT1

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Breast

Attributes

Phase: Two
QA State: Under Review

Overview

No additional breast data available.

Performance Comment

PTPMT1 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Biomuta

Mutation Statistics

Gene Name: PTPMT1
UniProt Accession #: Q8WUK0
Mutated Sites Count: 21
Associated Pubmed ID Count 4
CancerDO Count 19
Affected Protein Function Sites Count: 5

View in BioMuta