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You are here: Home / Biomarkers / POLR2L



This biomarker is also known as:
  • RPABC5,
  • RNA polymerase II 7.6 kDa subunit,
  • polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa,
  • DNA-directed RNA polymerases I, II, and III subunit RPABC5,
  • hsRPB10b,
  • RPB7.6,
  • DNA-directed RNA polymerase III subunit L,
  • RNA polymerases I, II, and III subunit ABC5,
  • RPB10beta,
  • polymerase (RNA) II (DNA directed) polypeptide L (7.6kD),
  • RPB10 homolog,
  • hRPB7.6,
  • RPB10,
  • RBP10,


POLR2L is the central component of RNA polymerase II. RNA polymerase II is the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit may be shared by the other two DNA-directed RNA polymerases, I and III. RNA polymerases, or Pols, are composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is thought to be part of the core element with the central large cleft.


QA State: Curated
Type: Protein
Short Name:


There are no datasets associated with this biomarker.


The following organs have data associated with this biomarker…



Phase: Two
QA State: Under Review


No additional breast data available.

Performance Comment

POLR2L was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.


This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at if you should have access to this biomarker.


Mutation Statistics

Gene Name: POLR2L
UniProt Accession #: P62875
Mutated Sites Count: 5
Associated Pubmed ID Count 0
CancerDO Count 5
Affected Protein Function Sites Count: 1

View in BioMuta