Aliases:This biomarker is also known as:
- DNA-directed RNA polymerases I, II, and III subunit RPABC5,
- DNA-directed RNA polymerase III subunit L,
- polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa,
- RNA polymerases I, II, and III subunit ABC5,
- RPB10 homolog,
- polymerase (RNA) II (DNA directed) polypeptide L (7.6kD),
- RNA polymerase II 7.6 kDa subunit,
POLR2L is the central component of RNA polymerase II. RNA polymerase II is the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit may be shared by the other two DNA-directed RNA polymerases, I and III. RNA polymerases, or Pols, are composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is thought to be part of the core element with the central large cleft.
There are no datasets associated with this biomarker.
The following organs have data associated with this biomarker…
|QA State:||Under Review|
No additional breast data available.
POLR2L was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.
- Discovery and preliminary confirmation of novel early detection biomarkers for triple-negative breast cancer using preclinical plasma samples from the Women's Health Initiative observational study.
- Plasma biomarker profiles differ depending on breast cancer subtype but RANTES is consistently increased.
|UniProt Accession #:||P62875|
|Mutated Sites Count:||7|
|Associated Pubmed ID Count||0|
|Affected Protein Function Sites Count:||4|