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You are here: Home / Biomarkers / POLR2L

POLR2L

Basics

Aliases:
This biomarker is also known as:
  • RPABC5,
  • RNA polymerase II 7.6 kDa subunit,
  • polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa,
  • DNA-directed RNA polymerases I, II, and III subunit RPABC5,
  • hsRPB10b,
  • RPB7.6,
  • DNA-directed RNA polymerase III subunit L,
  • RNA polymerases I, II, and III subunit ABC5,
  • RPB10beta,
  • polymerase (RNA) II (DNA directed) polypeptide L (7.6kD),
  • RPB10 homolog,
  • hRPB7.6,
  • RPB10,
  • RBP10,

Description…

POLR2L is the central component of RNA polymerase II. RNA polymerase II is the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit may be shared by the other two DNA-directed RNA polymerases, I and III. RNA polymerases, or Pols, are composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is thought to be part of the core element with the central large cleft.

Attributes

QA State: Curated
Type: Protein
Short Name:
HGNC Name: POLR2L

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Breast

Attributes

Phase: Two
QA State: Under Review

Overview

No additional breast data available.

Performance Comment

POLR2L was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Biomuta

Mutation Statistics

Gene Name: POLR2L
UniProt Accession #: P62875
Mutated Sites Count: 5
Associated Pubmed ID Count 0
CancerDO Count 5
Affected Protein Function Sites Count: 1

View in BioMuta