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PDGFA

Basics

Aliases:
This biomarker is also known as:
  • platelet-derived growth factor alpha polypeptide,
  • PDGF,
  • Platelet-derived growth factor,

Description…

PDGFA, or platelet-derived growth factor alpha polypeptide, is a member of the platelet-derived growth factor family. PDGFA is a growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. There are four members of the PDGF family, characterized by a motif of eight cysteines. PDGFA exists as either a homodimer or a heterodimer with PDGFB (platelet-derived growth factor beta polypeptide).

Attributes

QA State: Curated
Type: Protein
Short Name:
HGNC Name: PDGFA

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Breast

Attributes

Phase: Two
QA State: Under Review

Overview

No additional breast data available.

Performance Comment

PDGFA was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Biomuta

Mutation Statistics

Gene Name: PDGFA
UniProt Accession #: P04085
Mutated Sites Count: 35
Associated Pubmed ID Count 8
CancerDO Count 19
Affected Protein Function Sites Count: 5

View in BioMuta