PDGFA
Basics
Aliases:
This biomarker is also known as:- PDGF,
- Platelet-derived growth factor,
- platelet-derived growth factor alpha polypeptide,
Description…
PDGFA, or platelet-derived growth factor alpha polypeptide, is a member of the platelet-derived growth factor family. PDGFA is a growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. There are four members of the PDGF family, characterized by a motif of eight cysteines. PDGFA exists as either a homodimer or a heterodimer with PDGFB (platelet-derived growth factor beta polypeptide).
Attributes
| QA State: | Curated |
|---|---|
| Type: | Protein |
| Short Name: | |
| HGNC Name: | PDGFA |
Datasets
There are no datasets associated with this biomarker.
Organs
The following organs have data associated with this biomarker…
Breast
Attributes
| Phase: | Two |
|---|---|
| QA State: | Under Review |
Overview
No additional breast data available.
Performance Comment
PDGFA was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.
Studies
This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.
Publications
- Plasma biomarker profiles differ depending on breast cancer subtype but RANTES is consistently increased.
- Discovery and preliminary confirmation of novel early detection biomarkers for triple-negative breast cancer using preclinical plasma samples from the Women's Health Initiative observational study.
Resources
External Resources for PDGFA
Gene
Protein
Other
Biomuta
Mutation Statistics
| Gene Name: | PDGFA |
|---|---|
| UniProt Accession #: | P04085 |
| Mutated Sites Count: | 35 |
| Associated Pubmed ID Count | 8 |
| CancerDO Count | 19 |
| Affected Protein Function Sites Count: | 5 |
