PDGFA
Basics
Aliases:
This biomarker is also known as:- platelet-derived growth factor alpha polypeptide,
- PDGF,
- Platelet-derived growth factor,
Description…
PDGFA, or platelet-derived growth factor alpha polypeptide, is a member of the platelet-derived growth factor family. PDGFA is a growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. There are four members of the PDGF family, characterized by a motif of eight cysteines. PDGFA exists as either a homodimer or a heterodimer with PDGFB (platelet-derived growth factor beta polypeptide).
Attributes
| QA State: | Curated |
|---|---|
| Type: | Protein |
| Short Name: | |
| HGNC Name: | PDGFA |
Datasets
There are no datasets associated with this biomarker.
Organs
The following organs have data associated with this biomarker…
Breast
Attributes
| Phase: | Two |
|---|---|
| QA State: | Under Review |
Overview
No additional breast data available.
Performance Comment
PDGFA was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.
Studies
This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.
Publications
- Discovery and preliminary confirmation of novel early detection biomarkers for triple-negative breast cancer using preclinical plasma samples from the Women's Health Initiative observational study.
- Plasma biomarker profiles differ depending on breast cancer subtype but RANTES is consistently increased.
Resources
Gene
- HGNC entry for PDGFA from Genenames
- KEGG entry for PDGFA from Genome.jp
- Entrez entry for PDGFA all NCBI Databasese
- Human GEO Profiles for PDGFA from NCBI GEO Profiles
- Human Geo Datasets containing term PDGFA from NCBI GEO Datasets
- GWAS Study Datasets containing gene PDGFA from GWAS
- Human Single Nucleotide Polymorphisms info for PDGFA
- Human Gene(s) with 'PDGFA' as Gene Name/Alias
- Human Gene RefSeq for PDGFA from NCBI
- GeneCards entry for human PDGFA
Protein
- UniProtKB/Swiss-Prot entry for PDGFA from Uniprot
- Human Protein RefSeq for PDGFA from NCBI
- FDA web page describing approval of PDGFA
Other
Biomuta
Mutation Statistics
| Gene Name: | PDGFA |
|---|---|
| UniProt Accession #: | P04085 |
| Mutated Sites Count: | 35 |
| Associated Pubmed ID Count | 8 |
| CancerDO Count | 19 |
| Affected Protein Function Sites Count: | 5 |
