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You are here: Home / Biomarkers / PCCA

PCCA

Basics

Aliases:
This biomarker is also known as:
  • PCCase subunit alpha,
  • EC 6.4.1.3,
  • Propanoyl-CoA:carbon dioxide ligase subunit alpha,
  • PCCase alpha subunit,
  • pccA complementation group,
  • propionyl Coenzyme A carboxylase, alpha polypeptide,
  • propionyl CoA carboxylase, alpha polypeptide,
  • propanoyl-CoA:carbon dioxide ligase alpha subunit,
  • propionyl-CoA carboxylase alpha chain, mitochondrial,

Description…

PCCA, or propionyl CoA carboxylase, alpha polypeptide, is the alpha subunit of the heterodimeric mitochondrial enzyme Propionyl-CoA carboxylase. The beta subunit is PCCB. The enzyme deficiency propionic acidemia results from mutations in either PCCA or PCCB. Several isoforms for this gene have been identified, coded by multiple transcript variants.

Attributes

QA State: Curated
Type: Protein
Short Name:
HGNC Name: PCCA

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Breast

Attributes

Phase: Two
QA State: Under Review

Overview

No additional breast data available.

Performance Comment

PCCA was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Biomuta

Mutation Statistics

Gene Name: PCCA
UniProt Accession #: P05165
Mutated Sites Count: 150
Associated Pubmed ID Count 13
CancerDO Count 21
Affected Protein Function Sites Count: 3

View in BioMuta