Skip to content. | Skip to navigation

National Cancer Institute U.S. National Institutes of Health www.cancer.gov

Navigation

Personal tools

You are here: Home / Biomarkers / PARK7

PARK7

Basics

Aliases:
This biomarker is also known as:
  • DJ1,
  • Parkinson disease protein 7,
  • Parkinson disease (autosomal recessive, early onset) 7,
  • DJ-1,
  • Oncogene DJ-1,
  • Protein DJ-1,

Description…

DJ-1, also known as PARK-7, belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. DJ-1 is highly expressed in pancreas, kidney, skeletal muscle, liver, testis and heart and is detected at slightly lower levels in placenta and brain.

Attributes

QA State: Accepted
Type: Protein
Short Name:
HGNC Name: PARK7

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Lung

Attributes

Phase: Three
QA State: Under Review

Overview

Validation study was conducted to determine whether DJ-1 antigens are associated with autoantibodies in sera collected at the pre-symptomatic stage of lung cancer.

Performance Comment

Supporting Study Data

The following studies/protocols provide evidence supporting PARK7 indications for the Lung…

No supporting studies or protocols found.

Organ-Specific Protocols

No organ-specific protocols defined.

Organ-Specific Publications

No organ-specific publications defined.

Organ-Specific Resources

No organ-specific resources defined.

Studies

No associated studies or protocols found.

Biomuta

Mutation Statistics

Gene Name: PARK7
UniProt Accession #: Q99497
Mutated Sites Count: 19
Associated Pubmed ID Count 4
CancerDO Count 12
Affected Protein Function Sites Count: 4

View in BioMuta