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P2RY14

Basics

Aliases:
This biomarker is also known as:
  • KIAA0001,
  • purinergic receptor P2Y, G-protein coupled, 14,
  • P2Y purinoceptor 14,
  • P2Y14,
  • GPR105,
  • G protein-coupled receptor 105,
  • G-protein coupled receptor 105,
  • Q15391,
  • P2Y14 receptor,
  • P2Y(14) receptor,
  • UDP-glucose receptor,
  • G protein coupled receptor for UDP-glucose,

Description…

P2RY14, or GPR105, is a G-protein coupled receptor that responds to extracellular purine and pyrimidine nucleotides. P2RY14 is not activated by ATP, ADP, UTP or ATP, but is a receptor for UDP-glucose and other UDP-sugars coupled to G-proteins. P2RY14 is thought to be involved in extending the known immune system functions of P2Y receptors by participating in the regulation of the stem cell compartment, and it may also play a role in neuroimmune function. Two transcript variants encoding the same protein have been identified for this gene. There are two transcript variants for this gene that result in the same protein.

Attributes

QA State: Curated
Type: Protein
Short Name:
HGNC Name: P2RY14

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Ovary

Attributes

Phase: Two
QA State: Under Review

Overview

No additional ovarian data available.

Performance Comment

P2RY14 (GPR105) was one of 50 tumor vasculature-associated genes with transmembrane or secreted protein products identified through expression profiling of ovarian cancer vascular cells. These 50 tumor vascular markers (TVMs) also had low or no expression in normal tissues. P2RY14 was not in the group of 13 selected for further validation.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Biomuta

Mutation Statistics

Gene Name: P2RY14
UniProt Accession #: Q15391
Mutated Sites Count: 69
Associated Pubmed ID Count 11
CancerDO Count 18
Affected Protein Function Sites Count: 4

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