Aliases:This biomarker is also known as:
- neuronal NOS,
- EC 18.104.22.168,
- Constitutive NOS,
- peptidyl-cysteine S-nitrosylase NOS1,
- constitutive NOS,
- NOS type I,
- Neuronal NOS,
- Peptidyl-cysteine S-nitrosylase NOS1,
- nitric oxide synthase 1 (neuronal),
- nitric oxide synthase, brain,
NOS1, or nitric oxide synthase 1 (neuronal), along with inducible nitric oxide synthase (NOS2) and endothelial nitric oxide synthase (NOS3), catalyze the generation of nitric oxide and L-citrulline from L-arginine and molecular oxygen. Nitric oxide is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter. NOS1 also displays antimicrobial and antitumoral activities.
There are no datasets associated with this biomarker.
The following organs have data associated with this biomarker…
|QA State:||Under Review|
No additional breast data available.
NOS1 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.
- Discovery and preliminary confirmation of novel early detection biomarkers for triple-negative breast cancer using preclinical plasma samples from the Women's Health Initiative observational study.
- Plasma biomarker profiles differ depending on breast cancer subtype but RANTES is consistently increased.
- HGNC entry for NOS1 from Genenames
- KEGG entry for NOS1 from Genome.jp
- Entrez entry for NOS1 all NCBI Databasese
- Human GEO Profiles for NOS1 from NCBI GEO Profiles
- Human Geo Datasets containing term NOS1 from NCBI GEO Datasets
- GWAS Study Datasets containing gene NOS1 from GWAS
- Human Single Nucleotide Polymorphisms info for NOS1
- Human Gene(s) with 'NOS1' as Gene Name/Alias
- Human Gene RefSeq for NOS1 from NCBI
- GeneCards entry for human NOS1
- UniProtKB/Swiss-Prot entry for NOS1 from Uniprot
- Human Protein RefSeq for NOS1 from NCBI
- FDA web page describing approval of NOS1
|UniProt Accession #:||P29475|
|Mutated Sites Count:||681|
|Associated Pubmed ID Count||36|
|Affected Protein Function Sites Count:||5|