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NELL1

Basics

Aliases:
This biomarker is also known as:
  • NRP1,
  • Nel-related protein 1,
  • NEL-like protein 1,
  • Protein kinase C-binding protein NELL1,
  • nel-like 1,

Description…

NELL1 is a cytoplasmic protein that contains epidermal growth factor (EGF)-like repeats. The encoded heterotrimeric protein may be involved in cell growth regulation and differentiation.

Attributes

QA State: Accepted
Type: Genomic
Short Name:
HGNC Name: NELL1

Organs

The following organs have data associated with this biomarker…

Esophagus

Attributes

Phase: Two
QA State: Accepted

Overview

Esphageal adenocarcinoma risk in Barrett's esophagus is increased 30- to 125- fold versus the general population. Among all Barrett's esophagus patients neoplastic progression occurs only once per 200 patient-years. Molecular markers (individual or in panel) would be useful to risk-stratify patients for more efficient surveillance endoscopy and to improve the early detection of progression.

Performance Comment

Promoter hypermethylation of NELL1 occurs early during Barrett's-associated esophageal neoplastic progression, and is a potential biomarker of poor prognosis in early-stage esophageal adenocarcinoma. Studies are ongoing.

Supporting Study Data

The following studies/protocols provide evidence supporting NELL1 indications for the Esophagus…

No supporting studies or protocols found.

Organ-Specific Protocols

No organ-specific protocols defined.

Organ-Specific Publications

No organ-specific publications defined.

Organ-Specific Resources

No organ-specific resources defined.

Studies

No associated studies or protocols found.

Biomuta

Mutation Statistics

Gene Name: NELL1
UniProt Accession #: Q92832
Mutated Sites Count: 532
Associated Pubmed ID Count 22
CancerDO Count 26
Affected Protein Function Sites Count: 5

View in BioMuta