NDUFA10
Basics
Aliases:
This biomarker is also known as:- CI-42KD,
- Complex I-42kD,
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,
- NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa,
- NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10 (42kD),
- NADH-ubiquinone oxidoreductase 42 kDa subunit,
- CI-42kD,
- complex I 42kDa subunit,
- CI-42k,
Description…
NDUFA10 is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Mammalian complex I is the first enzyme complex in the electron transport chain of mitochondria. It is composed of 45 different subunits. This protein is a component of the hydrophobic protein fraction and has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain.
Attributes
| QA State: | Curated |
|---|---|
| Type: | Protein |
| Short Name: | |
| HGNC Name: | NDUFA10 |
Datasets
There are no datasets associated with this biomarker.
Organs
The following organs have data associated with this biomarker…
Breast
Attributes
| Phase: | Two |
|---|---|
| QA State: | Under Review |
Overview
No additional breast data available.
Performance Comment
NDUFA10 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.
Studies
This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.
Publications
- Discovery and preliminary confirmation of novel early detection biomarkers for triple-negative breast cancer using preclinical plasma samples from the Women's Health Initiative observational study.
- Plasma biomarker profiles differ depending on breast cancer subtype but RANTES is consistently increased.
Resources
External Resources for NDUFA10
Gene
Protein
Other
Biomuta
Mutation Statistics
| Gene Name: | NDUFA10 |
|---|---|
| UniProt Accession #: | O95299 |
| Mutated Sites Count: | 45 |
| Associated Pubmed ID Count | 7 |
| CancerDO Count | 19 |
| Affected Protein Function Sites Count: | 4 |
