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NDUFA10

Basics

Aliases:
This biomarker is also known as:
  • NADH-ubiquinone oxidoreductase 42 kDa subunit,
  • complex I 42kDa subunit,
  • CI-42k,
  • CI-42KD,
  • Complex I-42kD,
  • CI-42kD,
  • NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa,
  • NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10 (42kD),
  • NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,

Description…

NDUFA10 is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Mammalian complex I is the first enzyme complex in the electron transport chain of mitochondria. It is composed of 45 different subunits. This protein is a component of the hydrophobic protein fraction and has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain.

Attributes

QA State: Curated
Type: Protein
Short Name:
HGNC Name: NDUFA10

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Breast

Attributes

Phase: Two
QA State: Under Review

Overview

No additional breast data available.

Performance Comment

NDUFA10 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Publications

Resources

Biomuta

Mutation Statistics

Gene Name: NDUFA10
UniProt Accession #: O95299
Mutated Sites Count: 43
Associated Pubmed ID Count 6
CancerDO Count 16
Affected Protein Function Sites Count: 2

View in BioMuta