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MYCBP

Basics

Aliases:
This biomarker is also known as:
  • Associate of Myc 1,
  • associate of myc-1,
  • C-Myc-binding protein,
  • AMY1,
  • AMY-1,
  • c-myc binding protein,

Description…

MYCBP, or MYC binding protein, or C-MYC binding protein, binds to the N-terminus of the oncogenic protein MYC, also known as C-MYC, enhancing the ability of MYC to activate E box-dependent transcription. MYCBP is normally found in the cytoplasm, but it moves to the nucleus during the S phase of the cell cycle and associates with MYC.

Attributes

QA State: Curated
Type: Protein
Short Name:
HGNC Name: MYCBP

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Breast

Attributes

Phase: Two
QA State: Under Review

Overview

No additional breast data available.

Performance Comment

MYCBP was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Resources

External Resources for MYCBP

The protein encoded by this gene binds to the N-terminus of the oncogenic protein C-MYC, enhancing the ability of C-MYC to activate E box-dependent transcription. The encoded protein is normally found in the cytoplasm, but it translocates to the nucleus during S phase of the cell cycle and associates with C-MYC. This protein may be involved in spermatogenesis. This gene can be silenced by microRNA-22. Two transcript variants, one protein-coding and the other probably not protein-coding, have been found for this gene.

Gene

Protein

Other

No other associated resources found.

Biomuta

Mutation Statistics

Gene Name: MYCBP
UniProt Accession #: Q99417
Mutated Sites Count: 10
Associated Pubmed ID Count 3
CancerDO Count 10
Affected Protein Function Sites Count: 3

View in BioMuta