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MPPED2

Basics

Aliases:
This biomarker is also known as:
  • dJ1024C24.1,
  • FAM1B,
  • Fetal brain protein 239,
  • dJ873F21.1,
  • EC 3.1.-.-,
  • c11orf8,
  • fetal brain protein 239,
  • Hs.46638,
  • metallophosphoesterase domain-containing protein 2,
  • C11orf8,
  • metallophosphoesterase domain containing 2,
  • D11S302E,
  • metallophosphoesterase MPPED2,
  • Metallophosphoesterase domain-containing protein 2,
  • Q15777,
  • 239FB,
  • chromosome 11 open reading frame 8,

Description…

MPPED2 displays low metallophosphoesterase activity (in vitro) and may play a role in the development of the brain and nervous system (by similarity). Alternatively spliced transcript variants have been described.

Attributes

QA State: Curated
Type: Protein
Short Name:
HGNC Name: MPPED2

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Ovary

Attributes

Phase: Two
QA State: Under Review

Overview

Mpped2 expression has been shown to impair neuroblastoma tumorigenesis in mice.

Performance Comment

MPPED2 (C11ORF8) was one of 50 tumor vasculature-associated genes with transmembrane or secreted protein products identified through expression profiling of ovarian cancer vascular cells. These 50 tumor vascular markers (TVMs) also had low or no expression in normal tissues. MPPED2 (C11ORF8) was not in the group of 13 selected for further validation.

Prostate

Attributes

Phase: One
QA State: Under Review

Overview

Performance Comment

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Biomuta

Mutation Statistics

Gene Name: MPPED2
UniProt Accession #: Q15777
Mutated Sites Count: 74
Associated Pubmed ID Count 16
CancerDO Count 22
Affected Protein Function Sites Count: 5

View in BioMuta