Aliases:This biomarker is also known as:
- microRNA 21,
From NCBI Gene: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. miRNAs bind to complementary sequences in the 3' UTR of multiple target mRNAs, usually silencing the targeted mRNA. miRNAs may trigger the cleavage of their target molecules or act as translational repressors. miRNAs are thought to target approximatley 60% of all genes and are able to repress hundreds of targets each.
There are no datasets associated with this biomarker.
The following organs have data associated with this biomarker…
MIR21 has been associated with many types of cancer, including lung, breast, pancreatic, and prostate.
MIR21 is one of four members of a panel investigated as potential plasma biomarkers for non-small-cell lung cancer (NSCLC). The four members of the panel are MIR486-5p, MIR21, MIR126, MIR210.
- Lung cancer signatures in plasma based on proteome profiling of mouse tumor models.
- TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway.
- The state of molecular biomarkers for the early detection of lung cancer.
- Identification of plasma microRNA-21 as a biomarker for early detection and chemosensitivity of non-small cell lung cancer.