Aliases:This biomarker is also known as:
- cell surface glycoprotein P1H12,
- melanoma cell adhesion molecule,
- CD146 antigen,
- Melanoma-associated antigen MUC18,
- S-endo 1 endothelial-associated antigen,
- Cell surface glycoprotein P1H12,
- melanoma-associated antigen MUC18,
- melanoma-associated antigen A32,
- Melanoma cell adhesion molecule,
- melanoma adhesion molecule,
- cell surface glycoprotein MUC18,
- Melanoma-associated antigen A32,
From UniProtKB/Swiss-Prot: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.
There are no datasets associated with this biomarker.
The following organs have data associated with this biomarker…
Head & neck, NOS
No additional data available.
MCAM is one of eight genes on a panel of differentially methylated genes from normal and OSCC clinical samples from patients with heterogenous risk profiles chosen for further validation. The eight genes are: HOXA9, NID2, GATA4, KIF1A, EDNRB, MCAM, DCC, and CALCA.
|QA State:||Under Review|
|UniProt Accession #:||P43121|
|Mutated Sites Count:||74|
|Associated Pubmed ID Count||19|
|Affected Protein Function Sites Count:||4|