Aliases:This biomarker is also known as:
- Latent-transforming growth factor beta-binding protein 2,
- latent transforming growth factor beta binding protein 2,
- chromosome 14 open reading frame 141,
LTBP2, the largest member of the latent transforming growth factor (TGF)-beta binding protein family, possesses unique regions and is most similar to the fibrillins. It has thus been suggested that it may have multiple functions: as a member of the TGF-beta latent complex, as a structural component of microfibrils, and a role in cell adhesion. LTBP2 forms part of the large latent transforming growth factor beta precursor complex; removal is essential for activation of complex. It is expressed in lung, weakly expressed in heart, placenta, liver and skeletal muscle.
There are no datasets associated with this biomarker.
The following organs have data associated with this biomarker…
|QA State:||Under Review|
No additional ovarian data available.
LTBP2 was one of 50 tumor vasculature-associated genes with transmembrane or secreted protein products identified through expression profiling of ovarian cancer vascular cells. These 50 tumor vascular markers (TVMs) also had low or no expression in normal tissues. LTBP2 was not in the group of 13 selected for further validation.
|UniProt Accession #:||Q14767|
|Mutated Sites Count:||277|
|Associated Pubmed ID Count||23|
|Affected Protein Function Sites Count:||5|