Aliases:This biomarker is also known as:
- High molecular weight kininogen,
- kininogen 1,
- alpha-2-thiol proteinase inhibitor,
- Williams-Fitzgerald-Flaujeac factor,
- Fitzgerald factor,
Kininogens are inhibitors of thiol proteases. The KNG1 gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII. HMW-kininogen also inhibits the thrombin- and plasmin-induced aggregation of thrombocytes. LMW-kininogen inhibits the aggregation of thrombocytes. LMW-kininogen, in contrast to HMW-kininogen, is not involved in blood clotting.
|QA State:||Under Review|
There are no datasets associated with this biomarker.