Aliases:This biomarker is also known as:
- kallikrein-related peptidase 8,
- Tumor-associated differentially expressed gene 14 protein,
- kallikrein 8 (neuropsin/ovasin),
- Serine protease TADG-14,
- Serine protease 19,
KLK8, a member of the kallikrein subgroup of serine proteases, is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Kallikreins have been implicated in carcinogenesis, and some have potential as novel cancer and other disease biomarkers. KLK8 is one of fifteen kallikrein subfamily members located in a cluster on chromosome 19. The four isoforms of KLK8 are a result of alternate splicing of the gene. The isoforms exhibit distinct patterns of expression that suggest roles in brain plasticity and ovarian cancer.
There are no datasets associated with this biomarker.
The following organs have data associated with this biomarker…
KLK8 alone was not shown to be a strong predictor of ovarian cancer.
Despite many promising new markers for ovarian cancer, CA125 remains the single best biomarker in the phase II and phase III specimens tested in this study.
- HGNC entry for KLK8 from Genenames
- KEGG entry for KLK8 from Genome.jp
- Entrez entry for KLK8 all NCBI Databasese
- Human GEO Profiles for KLK8 from NCBI GEO Profiles
- Human Geo Datasets containing term KLK8 from NCBI GEO Datasets
- GWAS Study Datasets containing gene KLK8 from GWAS
- Human Single Nucleotide Polymorphisms info for KLK8
- Human Gene(s) with 'KLK8' as Gene Name/Alias
- Human Gene RefSeq for KLK8 from NCBI
- GeneCards entry for human KLK8
- UniProtKB/Swiss-Prot entry for KLK8 from Uniprot
- Human Protein RefSeq for KLK8 from NCBI
- FDA web page describing approval of KLK8
|UniProt Accession #:||O60259|
|Mutated Sites Count:||150|
|Associated Pubmed ID Count||15|
|Affected Protein Function Sites Count:||4|