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KLK6

Basics

Aliases:
This biomarker is also known as:
  • Kallikrein-6,
  • PRSS9,
  • Klk7,
  • Neurosin,
  • HK-6,
  • Zyme,
  • PRSS18,
  • Protease M,
  • KLK-6,
  • Serine protease 9,
  • kallikrein-related peptidase 6,
  • Serine protease 18,
  • SP59,
  • Bssp,

Description…

Serine protease M expressed on epithelial cell surface and released in ECM. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis. Overexpressed in primary breast tumors but not expressed in metastatic tumors.

Attributes

QA State: Accepted
Type: Protein
Short Name:
HGNC Name: KLK6

Organs

The following organs have data associated with this biomarker…

Ovary

Attributes

Phase: Three
QA State: Accepted

Overview

Amplification of a chromosome 19q region with the entire kallikrein family associated with ovarian cancer.

Performance Comment

Of the 28 ovarian cancer biomarkers tested in prediagnostic specimens, from the PLCO, CA125 remains the single best biomarker for ovarian cancer and has its strongest signal within six months of diagnosis. KLK6 alone was not a strong predictor.

Supporting Study Data

The following studies/protocols provide evidence supporting KLK6 indications for the Ovary…

No supporting studies or protocols found.

Organ-Specific Protocols

No organ-specific protocols defined.

Organ-Specific Publications

Organ-Specific Resources

No organ-specific resources defined.

Studies

No associated studies or protocols found.

Biomuta

Mutation Statistics

Gene Name: KLK6
UniProt Accession #: Q92876
Mutated Sites Count: 80
Associated Pubmed ID Count 6
CancerDO Count 16
Affected Protein Function Sites Count: 4

View in BioMuta