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KLK4

Basics

Aliases:
This biomarker is also known as:
  • Enamel matrix serine proteinase 1,
  • EMSP1,
  • PRSS17,
  • Kallikrein-like protein 1,
  • Serine protease 17,
  • Kallikrein-4,
  • Prostase,
  • Human kallikrein 4,
  • PSTS,
  • KLK-L1,
  • hK4,

Description…

The glandular kallikreins are a distinct group of serine proteases with molecular masses of 25,000 to 40,000. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Several human kallikrein genes have been isolated. hK4 is expressed in the prostate.

Attributes

QA State: Accepted
Type: Protein
Short Name:
HGNC Name: KLK4

Organs

The following organs have data associated with this biomarker…

Prostate

Attributes

Phase: One
QA State: Accepted

Overview

Kallikreins (KLKs) are highly conserved serine proteases that play key roles in a variety of physiological and pathological processes. KLK4 is regulated by androgens and is highly specific to prostate for expression. hK4 is intracellularly localized. KLK4 is predominantly expressed in the basal cells of the normal prostate gland and overexpressed in prostate cancer. hK4 has a unique structure and function compared with other members of the KLK family and may have a role in the biology and characterization of prostate cancer.

Performance Comment

hK2, hK4 and hK11 do not distinguish cases from controls in these populations.

Supporting Study Data

The following studies/protocols provide evidence supporting KLK4 indications for the Prostate…

No supporting studies or protocols found.

Organ-Specific Protocols

No organ-specific protocols defined.

Organ-Specific Publications

No organ-specific publications defined.

Organ-Specific Resources

No organ-specific resources defined.

Studies

No associated studies or protocols found.

Biomuta

Mutation Statistics

Gene Name: KLK4
UniProt Accession #: Q9Y5K2
Mutated Sites Count: 67
Associated Pubmed ID Count 13
CancerDO Count 23
Affected Protein Function Sites Count: 5

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