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PSA

Basics

Aliases:
This biomarker is also known as:
  • P-30 antigen,
  • prostate specific antigen,
  • semenogelase,
  • kallikrein-3,
  • Gamma-seminoprotein,
  • gamma-seminoprotein,
  • prostate-specific antigen,
  • EC 3.4.21.77,
  • Kallikrein-3,
  • Seminin,
  • KLK3,
  • KLK2A1,
  • seminin,
  • kallikrein-related peptidase 3,
  • Semenogelase,
  • hK3,
  • APS,
  • kallikrein 3, (prostate specific antigen),

Description…

KLK3, also known as PSA, or prostate specific antigen, a member of the kallikrein subgroup of serine proteases, is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Kallikreins are increasingly thought to be involved in carcinogenesis, and many act as cancer biomarkers. The product of the KLK3 gene is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum. KLK3, or PSA, is well known for its role in diagnosing and monitoring prostate cancer. There are several isoforms of KLK3, generated by alternate splicing and transcript variants.

Attributes

QA State: Curated
Type: Protein
Short Name:
HGNC Name: KLK3

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Breast

Attributes

Phase: One
QA State: Curated

Overview

No additional data available.

Performance Comment

Ninety biomarkers were measured using a series of multiplexed immunoassays and results analyzed by the EDRN data management center splitting the cases and controls into training and validation sets, excluding subjects with DCIS or atypical hyperplasia from the training phase. We found little evidence that any of these markers can discriminate women with invasive cancer from those with benign breast conditions.

Prostate

Attributes

Phase: One
QA State: Curated

Overview

The measurement of PSA, free PSA, and pro-PSA can help a patient determine whether to undergo biopsy if his PSA level is between 4 and 10 ng/mL.

Performance Comment

In July 2012 the FDA approved an assay measuring levels of [-2]proPSA, a form of pro-PSA, for monitoring and diagnostic purposes.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Biomuta

Mutation Statistics

Gene Name: KLK3
UniProt Accession #: P07288
Mutated Sites Count: 74
Associated Pubmed ID Count 13
CancerDO Count 17
Affected Protein Function Sites Count: 3

View in BioMuta

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