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ITGB1

Basics

Aliases:
This biomarker is also known as:
  • VLAB,
  • VLA-BETA,
  • integrin VLA-4 beta subunit,
  • VLA-4 subunit beta,
  • FNRB,
  • MDF2,
  • integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12),
  • GPIIA,
  • integrin beta-1,
  • MSK12,
  • CD29,
  • Fibronectin receptor subunit beta,
  • very late activation protein, beta polypeptide,
  • CD29 antigen,

Description…

ITGB1 is a beta subunit of the heterodimeric integrin protein. Integrins are ubiquitously expressed adhesion molecules composed of alpha and beta subunits. In mammals, 18 alpha and 8 beta subunits have been identified. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. Several protein isoforms have been identifed, arising from alternatively spliced transcript variants.

Attributes

QA State: Curated
Type: Protein
Short Name:
HGNC Name: ITGB1

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Breast

Attributes

Phase: Two
QA State: Under Review

Overview

No additional breast data is available.

Performance Comment

ITGB1 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Biomuta

Mutation Statistics

Gene Name: ITGB1
UniProt Accession #: P05556
Mutated Sites Count: 110
Associated Pubmed ID Count 16
CancerDO Count 24
Affected Protein Function Sites Count: 4

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