Aliases:This biomarker is also known as:
- Hybridoma growth factor,
- B-cell differentiation factor,
- Interleukin 6,
- interleukin 6 (interferon, beta 2),
- Interferon beta-2,
- CTL differentiation factor,
- B-cell stimulatory factor 2,
- B cell stimulatory factor-2,
Interleukin 6 (IL6) is a cytokine that is involved in inflammation and the maturation of B cells as well as induction of the acute phase response. In addition to inducing myeloma and plasmacytoma growth and nerve cell differentiation, it also plays an important role in the differentiation of B-cells into Ig-secreting cells involved in lymphocyte and monocyte differentiation. The IL6 protein is produced mainly at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The IL6 gene is involved in many inflammation-associated disease states, including diabetes mellitus, where it acts on insulin resistance, and systemic juvenile rheumatoid arthritis. IL6 is discharged into the bloodstream after muscle contraction.
There are no datasets associated with this biomarker.
The following organs have data associated with this biomarker…
IL6 alone is not a strong predictor of ovarian cancer.
Despite many promising new markers for ovarian cancer, CA125 remains the single best biomarker in the phase II and phase III specimens tested in this study.
- HGNC entry for IL6 from Genenames
- KEGG entry for IL6 from Genome.jp
- Entrez entry for IL6 all NCBI Databasese
- Human GEO Profiles for IL6 from NCBI GEO Profiles
- Human Geo Datasets containing term IL6 from NCBI GEO Datasets
- GWAS Study Datasets containing gene IL6 from GWAS
- Human Single Nucleotide Polymorphisms info for IL6
- Human Gene(s) with 'IL6' as Gene Name/Alias
- Human Gene RefSeq for IL6 from NCBI
- UniProtKB/Swiss-Prot entry for IL6 from Uniprot
- Human Protein RefSeq for IL6 from NCBI
- FDA web page describing approval of IL6
No other associated resources found.
|UniProt Accession #:||P05231|
|Mutated Sites Count:||41|
|Associated Pubmed ID Count||7|
|Affected Protein Function Sites Count:||4|