Skip to content. | Skip to navigation

National Cancer Institute U.S. National Institutes of Health


Personal tools

You are here: Home / Biomarkers / IL6



This biomarker is also known as:
  • Hybridoma growth factor,
  • CDF,
  • HGF,
  • B-cell differentiation factor,
  • HSF,
  • BSF2,
  • Interleukin 6,
  • IFN-beta-2,
  • interleukin 6 (interferon, beta 2),
  • Interferon beta-2,
  • CTL differentiation factor,
  • B-cell stimulatory factor 2,
  • IFNB2,
  • IL-6,
  • B cell stimulatory factor-2,
  • BSF-2,


Interleukin 6 (IL6) is a cytokine that is involved in inflammation and the maturation of B cells as well as induction of the acute phase response. In addition to inducing myeloma and plasmacytoma growth and nerve cell differentiation, it also plays an important role in the differentiation of B-cells into Ig-secreting cells involved in lymphocyte and monocyte differentiation. The IL6 protein is produced mainly at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The IL6 gene is involved in many inflammation-associated disease states, including diabetes mellitus, where it acts on insulin resistance, and systemic juvenile rheumatoid arthritis. IL6 is discharged into the bloodstream after muscle contraction.


QA State: Curated
Type: Protein
Short Name:
HGNC Name: IL6


There are no datasets associated with this biomarker.


The following organs have data associated with this biomarker…



Phase: Two
QA State: Curated


IL6 alone is not a strong predictor of ovarian cancer.

Performance Comment

Despite many promising new markers for ovarian cancer, CA125 remains the single best biomarker in the phase II and phase III specimens tested in this study.


This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at if you should have access to this biomarker.


Mutation Statistics

Gene Name: IL6
UniProt Accession #: P05231
Mutated Sites Count: 41
Associated Pubmed ID Count 7
CancerDO Count 17
Affected Protein Function Sites Count: 4

View in BioMuta