Aliases:This biomarker is also known as:
- cytokine synthesis inhibitory factor,
- T-cell growth inhibitory factor,
- interleukin 10,
From NCBI Gene: The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011]
There are no datasets associated with this biomarker.
The following organs have data associated with this biomarker…
No additional data available.
Ninety biomarkers were measured using a series of multiplexed immunoassays and results analyzed by the EDRN data management center splitting the cases and controls into training and validation sets, excluding subjects with DCIS or atypical hyperplasia from the training phase. We found little evidence that any of these markers can discriminate women with invasive cancer from those with benign breast conditions.
IL10 alone was not a strong predictor of ovarian cancer.
Despite many promising new markers for ovarian cancer, CA125 remains the single best biomarker in the phase II and phase III specimens tested in this study.
No associated publications found.
- HGNC entry for IL10 from Genenames
- KEGG entry for IL10 from Genome.jp
- Entrez entry for IL10 all NCBI Databasese
- Human GEO Profiles for IL10 from NCBI GEO Profiles
- Human Geo Datasets containing term IL10 from NCBI GEO Datasets
- GWAS Study Datasets containing gene IL10 from GWAS
- Human Single Nucleotide Polymorphisms info for IL10
- Human Gene(s) with 'IL10' as Gene Name/Alias
- Human Gene RefSeq for IL10 from NCBI
- GeneCards entry for human IL10
- UniProtKB/Swiss-Prot entry for IL10 from Uniprot
- Human Protein RefSeq for IL10 from NCBI
- FDA web page describing approval of IL10
|UniProt Accession #:||P22301|
|Mutated Sites Count:||29|
|Associated Pubmed ID Count||6|
|Affected Protein Function Sites Count:||4|