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ICAM1

Basics

Aliases:
This biomarker is also known as:
  • intercellular adhesion molecule 1,
  • ICAM-1,
  • P3.58,
  • Cell Surface Glycoprotein P3.58,
  • BB2,
  • CD54,
  • Human Rhinovirus Receptor,
  • CD54 Antigen,
  • Major group rhinovirus receptor,

Description…

From NCBI Gene: This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]

Attributes

QA State: Curated
Type: Protein
Short Name:
HGNC Name: ICAM1

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Breast

Attributes

Phase: One
QA State: Curated

Overview

No additional data available.

Performance Comment

Ninety biomarkers were measured using a series of multiplexed immunoassays and results analyzed by the EDRN data management center splitting the cases and controls into training and validation sets, excluding subjects with DCIS or atypical hyperplasia from the training phase. We found little evidence that any of these markers can discriminate women with invasive cancer from those with benign breast conditions.

Ovary

Attributes

Phase: Three
QA State: Under Review

Overview

ICAM1 alone was not shown to be a strong predictor of ovarian cancer.

Performance Comment

Despite many promising new markers for ovarian cancer, CA125 remains the single best biomarker in the phase II and phase III specimens tested in this study.

Pancreas

Attributes

Phase: Three
QA State: Under Review

Overview

Performance Comment

Despite many promising new markers for ovarian cancer, CA125 remains the single best biomarker in the phase II and phase III specimens tested in this study.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Publications

No associated publications found.

Biomuta

Mutation Statistics

Gene Name: ICAM1
UniProt Accession #: P05362
Mutated Sites Count: 70
Associated Pubmed ID Count 17
CancerDO Count 25
Affected Protein Function Sites Count: 5

View in BioMuta