Skip to content. | Skip to navigation

National Cancer Institute U.S. National Institutes of Health


Personal tools

You are here: Home / Biomarkers / HSPB8



This biomarker is also known as:
  • HSP22,
  • small stress protein-like protein HSP22,
  • protein kinase H11,
  • CMT2L,
  • Protein kinase H11,
  • HMN2A,
  • E2-induced gene 1 protein,
  • heat shock protein beta-8,
  • alpha-crystallin C chain,
  • Alpha-crystallin C chain,
  • HMN2,
  • DHMN2,
  • heat shock 22kDa protein 8,
  • E2IG1,
  • H11,
  • heat shock 27kDa protein 8,
  • CRYAC,
  • HspB8,
  • Small stress protein-like protein HSP22,


From NCBI Gene: The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008]


QA State: Curated
Type: Gene
Short Name:


There are no datasets associated with this biomarker.


The following organs have data associated with this biomarker…



Phase: One
QA State: Under Review


No additional prostate data available.

Performance Comment

Significance Analysis of Microarray (SAM) was used to develop a 7-gene classifier. The overall prediction accuracy and sensitivity is 71% and 76%, respectively. The inclusion of the Gleason sum to the seven-gene classifier raised the prediction accuracy and sensitivity to 83% and 76% respectively This prognostic signature is closely associated with biochemical recurrence in patients after radical prostatectomy. The seven genes are: RRAGD, PQBP1, HIST1H2BC, ALDH1A2, TRIM22, RBPMS, HSPB8.


This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at if you should have access to this biomarker.


Mutation Statistics

Gene Name: HSPB8
UniProt Accession #: Q9UJY1
Mutated Sites Count: 38
Associated Pubmed ID Count 9
CancerDO Count 17
Affected Protein Function Sites Count: 5

View in BioMuta