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HSD17B10

Basics

Aliases:
This biomarker is also known as:
  • mitochondrial ribonuclease P protein 2,
  • 17-beta-hydroxysteroid dehydrogenase 10,
  • XH98G2,
  • Mitochondrial RNase P protein 2,
  • short chain dehydrogenase/reductase family 5C, member 1,
  • ERAB,
  • EC 1.1.1.35,EC 1.1.1.178,
  • short chain type dehydrogenase/reductase XH98G2,
  • HADH2,
  • 17-beta-HSD 10,
  • 3-hydroxyacyl-CoA dehydrogenase type-2,
  • Mitochondrial ribonuclease P protein 2,
  • mental retardation, X-linked, syndromic 10,
  • MRPP2,
  • HCD2,
  • AB-binding alcohol dehydrogenase,
  • ABAD,
  • Short-chain type dehydrogenase/reductase XH98G2,
  • Endoplasmic reticulum-associated amyloid beta-peptide-binding protein,
  • Type II HADH,
  • short chain L-3-hydroxyacyl-CoA dehydrogenase type 2,
  • MHBD,
  • 3-hydroxyacyl-CoA dehydrogenase type II,
  • MRXS10,
  • MRX31,
  • hydroxyacyl-Coenzyme A dehydrogenase, type II, hydroxyacyl-Coenzyme A dehydrogenase, type II,
  • CAMR,
  • 3-hydroxy-2-methylbutyryl-CoA dehydrogenase,
  • MRX17,
  • SCHAD,
  • mitochondrial RNase P subunit 2,
  • amyloid-beta peptide binding alcohol dehydrogenase,
  • hydroxysteroid (17-beta) dehydrogenase 10,
  • DUPXp11.22,
  • endoplasmic reticulum-associated amyloid beta-peptide-binding protein,
  • SDR5C1,
  • 17b-HSD10,

Description…

HSD17B10, hydroxysteroid (17-beta) dehydrogenase 10, is a member of the short-chain dehydrogenase/reductase superfamily. HSD17B10 functions in mitochondrial tRNA maturation and catalyzes the oxidation of a wide variety of fatty acids, alcohols, and steroids. The protein is thought to play a role in the development of Alzheimer's disease. There are several alternatively spliced transcript variants, of which only two have been fully sequenced.

Attributes

QA State: Curated
Type: Protein
Short Name:
HGNC Name: HSD17B10

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Breast

Attributes

Phase: Two
QA State: Under Review

Overview

No additional breast data is available.

Performance Comment

HSD17B10 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Biomuta

Mutation Statistics

Gene Name: HSD17B10
UniProt Accession #: Q99714
Mutated Sites Count: 28
Associated Pubmed ID Count 0
CancerDO Count 11
Affected Protein Function Sites Count: 3

View in BioMuta