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HSD17B10

Basics

Aliases:
This biomarker is also known as:
  • 3-hydroxyacyl-CoA dehydrogenase type-2,
  • SCHAD,
  • DUPXp11.22,
  • 3-hydroxyacyl-CoA dehydrogenase type II,
  • MRPP2,
  • HADH2,
  • 17-beta-HSD 10,
  • CAMR,
  • HCD2,
  • mitochondrial RNase P subunit 2,
  • ERAB,
  • Endoplasmic reticulum-associated amyloid beta-peptide-binding protein,
  • AB-binding alcohol dehydrogenase,
  • mitochondrial ribonuclease P protein 2,
  • 17b-HSD10,
  • endoplasmic reticulum-associated amyloid beta-peptide-binding protein,
  • mental retardation, X-linked, syndromic 10,
  • Type II HADH,
  • short chain dehydrogenase/reductase family 5C, member 1,
  • MRX17,
  • amyloid-beta peptide binding alcohol dehydrogenase,
  • SDR5C1,
  • Short-chain type dehydrogenase/reductase XH98G2,
  • MRX31,
  • short chain L-3-hydroxyacyl-CoA dehydrogenase type 2,
  • 3-hydroxy-2-methylbutyryl-CoA dehydrogenase,
  • XH98G2,
  • hydroxyacyl-Coenzyme A dehydrogenase, type II, hydroxyacyl-Coenzyme A dehydrogenase, type II,
  • MRXS10,
  • short chain type dehydrogenase/reductase XH98G2,
  • EC 1.1.1.35,EC 1.1.1.178,
  • MHBD,
  • hydroxysteroid (17-beta) dehydrogenase 10,
  • ABAD,
  • 17-beta-hydroxysteroid dehydrogenase 10,
  • Mitochondrial ribonuclease P protein 2,
  • Mitochondrial RNase P protein 2,

Description…

HSD17B10, hydroxysteroid (17-beta) dehydrogenase 10, is a member of the short-chain dehydrogenase/reductase superfamily. HSD17B10 functions in mitochondrial tRNA maturation and catalyzes the oxidation of a wide variety of fatty acids, alcohols, and steroids. The protein is thought to play a role in the development of Alzheimer's disease. There are several alternatively spliced transcript variants, of which only two have been fully sequenced.

Attributes

QA State: Curated
Type: Protein
Short Name:
HGNC Name: HSD17B10

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Breast

Attributes

Phase: Two
QA State: Under Review

Overview

No additional breast data is available.

Performance Comment

HSD17B10 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Biomuta

Mutation Statistics

Gene Name: HSD17B10
UniProt Accession #: Q99714
Mutated Sites Count: 20
Associated Pubmed ID Count 0
CancerDO Count 10
Affected Protein Function Sites Count: 3

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