Aliases:This biomarker is also known as:
- hepcidin antimicrobial peptide,
- Putative liver tumor regressor,
- Liver-expressed antimicrobial peptide 1,
HEPC, also known as HAMP, is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure.
There are no datasets associated with this biomarker.
The following organs have data associated with this biomarker…
HAMP alone or as a member of a panel was not a strong predictor of ovarian cancer. CA125 alone remains a more effective biomarker.
Of the 28 ovarian cancer biomarkers tested in prediagnostic specimens, from the PLCO, CA125 remains the single best biomarker for ovarian cancer and has its strongest signal within six months of diagnosis. HAMP alone was not a strong predictor.
- HGNC entry for HAMP from Genenames
- KEGG entry for HAMP from Genome.jp
- Entrez entry for HAMP all NCBI Databasese
- Human GEO Profiles for HAMP from NCBI GEO Profiles
- Human Geo Datasets containing term HAMP from NCBI GEO Datasets
- GWAS Study Datasets containing gene HAMP from GWAS
- Human Single Nucleotide Polymorphisms info for HAMP
- Human Gene(s) with 'HAMP' as Gene Name/Alias
- Human Gene RefSeq for HAMP from NCBI
- UniProtKB/Swiss-Prot entry for HAMP from Uniprot
- Human Protein RefSeq for HAMP from NCBI
- FDA web page describing approval of HAMP
No other associated resources found.
|UniProt Accession #:||P81172|
|Mutated Sites Count:||15|
|Associated Pubmed ID Count||5|
|Affected Protein Function Sites Count:||4|