Aliases:This biomarker is also known as:
- EC 18.104.22.168,
- S-(hydroxyalkyl)glutathione lyase,
- Glutathione S-transferase zeta 1,
- maleylacetoacetate isomerase,
- EC 22.214.171.124,
- glutathione s-transferase Zeta 1,
- glutathione transferase zeta 1,
- glutathione S-aryltransferase,
- glutathione S-aralkyltransferase,
- glutathione S-alkyltransferase,
- maleylacetone isomerase,
The GSTZ1 gene product, glutathione transferase zeta 1, is a member of the glutathione S-transferase (GSTs) super-family which encodes multifunctional enzymes important in the detoxification of electrophilic molecules, including carcinogens, mutagens, and several therapeutic drugs, by conjugation with glutathione. GSTZ1 is also involved in the catabolism of phenylalanine and tyrosine. Thus defects in this enzyme may lead to severe metabolic disorders including alkaptonuria, phenylketonuria and tyrosinaemia. Several transcript variants of this gene encode multiple protein isoforms.
|QA State:||Under Review|
There are no datasets associated with this biomarker.