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GNB4

Basics

Aliases:
This biomarker is also known as:
  • G protein beta-4 subunit,
  • transducin beta chain 4,
  • guanine nucleotide binding protein (G protein), beta polypeptide 4,
  • guanine nucleotide binding protein beta subunit 4,
  • guanine nucleotide-binding protein subunit beta-4,
  • Transducin beta chain 4,

Description…

GNB4 is the beta subunit of a heterotrimeric guanine nucleotide-binding protein (G protein). These proteins also have alpha and gamma subunits. GNB4 and other beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Each type of subunit is encoded by families of related genes.

Attributes

QA State: Curated
Type: Protein
Short Name:
HGNC Name: GNB4

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Breast

Attributes

Phase: Two
QA State: Under Review

Overview

No additional breast data available.

Performance Comment

GNB4 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Biomuta

Mutation Statistics

Gene Name: GNB4
UniProt Accession #: Q9HAV0
Mutated Sites Count: 49
Associated Pubmed ID Count 12
CancerDO Count 21
Affected Protein Function Sites Count: 5

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