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GADD45B

Basics

Aliases:
This biomarker is also known as:
  • Negative growth regulatory protein MyD118,
  • negative growth regulatory protein MyD118,
  • GADD45BETA,
  • Myeloid differentiation primary response protein MyD118,
  • myeloid differentiation primary response protein MyD118,
  • growth arrest and DNA damage-inducible protein GADD45 beta,
  • MYD118,
  • growth arrest and DNA-damage-inducible, beta,
  • DKFZP566B133,

Description…

growth arrest and DNA-damage-inducible, beta

Attributes

QA State: Curated
Type: Gene
Short Name:
HGNC Name: GADD45B

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Prostate

Attributes

Phase: One
QA State: Curated

Overview

No additional prostate data available.

Performance Comment

19 common probe sets (15 unique genes) were used to develop a PAM-based classifier, which had an average accuracy of 87% when it was tested on 47 independent tumor-adjacent stroma samples. The 15 genes represented in the classifier are: GADD45B, CDKN1A, NLRP1, ERBB3, FMO5, KIAA0746///SERINC2, AMFR, DPP4, PGC, YWHAE, EHF, TF, TNFSF10, EIF5A, TGM4. This is the first general tumor microenvironment-based prognostic classifier. Tumor-adjacent prostate cancer stroma contains numerous changes in gene expression at the time of diagnosis that correlate with the chance of relapse following prostatectomy. These results indicate that the prostate cancer microenvironment exhibits reproducible changes useful for predicting outcomes for patients.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Resources

External Resources for GADD45B

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth.

Gene

Protein

Other

Biomuta

Mutation Statistics

Gene Name: GADD45B
UniProt Accession #: O75293
Mutated Sites Count: 12
Associated Pubmed ID Count 1
CancerDO Count 10
Affected Protein Function Sites Count: 4

View in BioMuta