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This biomarker is also known as:
  • FSH-beta,
  • Follitropin beta chain,
  • follitropin, beta chain,
  • follicle stimulating hormone, beta polypeptide,
  • Follitropin subunit beta,
  • follicle-stimulating hormone beta subunit,
  • FSHB,
  • FSH-B,


The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] Defects in FSHB are a cause of isolated follicle-stimulating hormone deficiency. Selective follicle-stimulating hormone deficiency is an uncommon cause of infertility, producing amenorrhea and hypogonadism in women and oligo or azoospermia with normal testosterone levels in normally virilised men. FSHB belongs to the glycoprotein hormones subunit beta family. There are two transcript variants from alternative splicing that each encode the same protein.


QA State: Curated
Type: Protein
Short Name:


There are no datasets associated with this biomarker.


The following organs have data associated with this biomarker…



Phase: Three
QA State: Curated


It is uncertain if FSH levels are related to ovarian cancer risk. Conclusions from different studies show conflicting results.

Performance Comment

Despite many promising new markers for ovarian cancer, CA125 remains the single best biomarker in the phase II and phase III specimens tested in this study.


This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at if you should have access to this biomarker.


Mutation Statistics

Gene Name: FSHB
UniProt Accession #: P01225
Mutated Sites Count: 32
Associated Pubmed ID Count 7
CancerDO Count 17
Affected Protein Function Sites Count: 2

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