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FMO5

Basics

Aliases:
This biomarker is also known as:
  • Hepatic flavin-containing monooxygenase 5,
  • Dimethylaniline oxidase 5,
  • dimethylaniline oxidase 5,
  • flavin containing monooxygenase 5,
  • dimethylaniline monooxygenase [N-oxide-forming] 5,
  • EC 1.14.13.8,
  • hepatic flavin-containing monooxygenase 5,
  • FMO 5,

Description…

flavin containing monooxygenase 5

Attributes

QA State: Curated
Type: Gene
Short Name:
HGNC Name: FMO5

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Prostate

Attributes

Phase: One
QA State: Under Review

Overview

No additional prostate data available.

Performance Comment

19 common probe sets (15 unique genes) were used to develop a PAM-based classifier, which had an average accuracy of 87% when it was tested on 47 independent tumor-adjacent stroma samples. The 15 genes represented in the classifier are: GADD45B, CDKN1A, NLRP1, ERBB3, FMO5, KIAA0746///SERINC2, AMFR, DPP4, PGC, YWHAE, EHF, TF, TNFSF10, EIF5A, TGM4. This is the first general tumor microenvironment-based prognostic classifier. Tumor-adjacent prostate cancer stroma contains numerous changes in gene expression at the time of diagnosis that correlate with the chance of relapse following prostatectomy. These results indicate that the prostate cancer microenvironment exhibits reproducible changes useful for predicting outcomes for patients.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Resources

External Resources for FMO5

Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants.

Gene

Protein

Other

Biomuta

Mutation Statistics

Gene Name: FMO5
UniProt Accession #: P49326
Mutated Sites Count: 80
Associated Pubmed ID Count 11
CancerDO Count 19
Affected Protein Function Sites Count: 4

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