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EPSTI1

Basics

Aliases:
This biomarker is also known as:
  • epithelial stromal interaction protein 1,
  • MGC29634,
  • epithelial stromal interaction 1 (breast),
  • BRESI1,
  • Q96J88,
  • epithelial-stromal interaction protein 1,

Description…

EPSTI1 is highly expressed in placenta, small intestine, spleen, kidney, thymus, liver, salivary gland and testes. There are three isoforms of this protein, produced by alternative splicing.

Attributes

QA State: Curated
Type: Protein
Short Name:
HGNC Name: EPSTI1

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Ovary

Attributes

Phase: Two
QA State: Under Review

Overview

No specific ovarian data available, however EPSTI1 has been found to be highly expressed in breast cancer.

Performance Comment

EPSTI1 was one of 50 tumor vasculature-associated genes with transmembrane or secreted protein products identified through expression profiling of ovarian cancer vascular cells. These 50 tumor vascular markers (TVMs) also had low or no expression in normal tissues. EPSTI1 was not in the group of 13 selected for further validation.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Resources

External Resources for EPSTI1

The protein encoded by this gene has been shown to promote tumor invasion and metastasis in some invasive cancer cells when overexpressed. Expression of this gene has been shown to be upregulated by direct binding of the Kruppel like factor 8 protein to promoter sequences. The translated protein interacts with the amino terminal region of the valosin containing protein gene product, resulting in the nuclear translocation of the nuclear factor kappa B subunit 1 gene product, and activation of target genes. Overexpression of this gene has been observed in some breast cancers and in some individuals with systemic lupus erythematosus (SLE).

Gene

Protein

Other

Biomuta

Mutation Statistics

Gene Name: EPSTI1
UniProt Accession #: Q96J88
Mutated Sites Count: 58
Associated Pubmed ID Count 7
CancerDO Count 15
Affected Protein Function Sites Count: 3

View in BioMuta