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This biomarker is also known as:
  • histone acetyltransferase p300,
  • p300 HAT,
  • E1A-associated protein p300,
  • RSTS2,
  • p300,
  • E1A-binding protein, 300kD,
  • KAT3B,
  • E1A binding protein p300,
  • P300,
  • EC,


EP300, or E1A binding protein p300, functions as a histone acetyltransferase and regulates transcription via chromatin remodeling. EP300 is important in the processes of cell proliferation and differentiation, and also functions as acetyltransferase for nonhistone targets. EP300 mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF.


QA State: Curated
Type: Protein
Short Name:
HGNC Name: EP300


There are no datasets associated with this biomarker.


The following organs have data associated with this biomarker…



Phase: Two
QA State: Under Review


No additional breast data available.

Performance Comment

EP300 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.


This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at if you should have access to this biomarker.


Mutation Statistics

Gene Name: EP300
UniProt Accession #: Q09472
Mutated Sites Count: 352
Associated Pubmed ID Count 50
CancerDO Count 27
Affected Protein Function Sites Count: 6

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