Aliases:This biomarker is also known as:
- histone acetyltransferase p300,
- p300 HAT,
- E1A-binding protein, 300kD,
- EC 18.104.22.168,
- E1A-associated protein p300,
- E1A binding protein p300,
EP300, or E1A binding protein p300, functions as a histone acetyltransferase and regulates transcription via chromatin remodeling. EP300 is important in the processes of cell proliferation and differentiation, and also functions as acetyltransferase for nonhistone targets. EP300 mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF.
There are no datasets associated with this biomarker.
The following organs have data associated with this biomarker…
|QA State:||Under Review|
No additional breast data available.
EP300 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.
- Discovery and preliminary confirmation of novel early detection biomarkers for triple-negative breast cancer using preclinical plasma samples from the Women's Health Initiative observational study.
- Plasma biomarker profiles differ depending on breast cancer subtype but RANTES is consistently increased.
- HGNC entry for EP300 from Genenames
- KEGG entry for EP300 from Genome.jp
- Entrez entry for EP300 all NCBI Databasese
- Human GEO Profiles for EP300 from NCBI GEO Profiles
- Human Geo Datasets containing term EP300 from NCBI GEO Datasets
- GWAS Study Datasets containing gene EP300 from GWAS
- Human Single Nucleotide Polymorphisms info for EP300
- Human Gene(s) with 'EP300' as Gene Name/Alias
- Human Gene RefSeq for EP300 from NCBI
- GeneCards entry for human EP300
- UniProtKB/Swiss-Prot entry for EP300 from Uniprot
- Human Protein RefSeq for EP300 from NCBI
- FDA web page describing approval of EP300
|UniProt Accession #:||Q09472|
|Mutated Sites Count:||353|
|Associated Pubmed ID Count||51|
|Affected Protein Function Sites Count:||6|