Aliases:This biomarker is also known as:
- Mammary Tumor-Associated Protein INT6,
- Eukaryotic Translation Initiation Factor 3, Subunit 6 48kDa,
- Murine Mammary Tumor Integration Site 6 (Oncogene Homolog),
- Eukaryotic Translation Initiation Factor 3 Subunit E,
- EIF-3 P48,
- Eukaryotic Translation Initiation Factor 3, Subunit E,
- Eukaryotic Translation Initiation Factor 3 Subunit 6,
- Eukaryotic Translation Initiation Factor 3, Subunit 6 (48kD),
- Viral Integration Site Protein INT-6 Homolog,
From UniProtKB/Swiss-Prot: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins.
|QA State:||Under Review|
There are no datasets associated with this biomarker.