Aliases:This biomarker is also known as:
- Receptor tyrosine-protein kinase erbB-1,
- Proto-oncogene c-ErbB-1,
- cell growth inhibiting protein 40,
- avian erythroblastic leukemia viral (v-erb-b) oncogene homolog,
- Epidermal growth factor receptor,
- cell proliferation-inducing protein 61,
- epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog),
From NCBI Gene: The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
There are no datasets associated with this biomarker.
The following organs have data associated with this biomarker…
No additional data available.
Ninety biomarkers were measured using a series of multiplexed immunoassays and results analyzed by the EDRN data management center splitting the cases and controls into training and validation sets, excluding subjects with DCIS or atypical hyperplasia from the training phase. We found little evidence that any of these markers can discriminate women with invasive cancer from those with benign breast conditions.
|QA State:||Under Review|
|QA State:||Under Review|
P53, EGFR and HER-2/neu are the most frequently studied molecular biological parameters in epithelial ovarian cancer. Elevated EGFR is associated with less favorable disease outcome in ovarian cancer, related in part to EGFR activation of signaling cascades that lead to enhanced matrix metalloproteinase expression and/or function.
Of the 28 ovarian cancer biomarkers tested in prediagnostic specimens, from the PLCO, CA125 remains the single best biomarker for ovarian cancer and has its strongest signal within six months of diagnosis. EGFR alone was not a strong predictor.
- HGNC entry for EGFR from Genenames
- KEGG entry for EGFR from Genome.jp
- Entrez entry for EGFR all NCBI Databasese
- Human GEO Profiles for EGFR from NCBI GEO Profiles
- Human Geo Datasets containing term EGFR from NCBI GEO Datasets
- GWAS Study Datasets containing gene EGFR from GWAS
- Human Single Nucleotide Polymorphisms info for EGFR
- Human Gene(s) with 'EGFR' as Gene Name/Alias
- Human Gene RefSeq for EGFR from NCBI
- UniProtKB/Swiss-Prot entry for EGFR from Uniprot
- Human Protein RefSeq for EGFR from NCBI
- FDA web page describing approval of EGFR
|UniProt Accession #:||P00533|
|Mutated Sites Count:||416|
|Associated Pubmed ID Count||329|
|Affected Protein Function Sites Count:||8|