Navigation

Personal tools

Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted.

The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit https://cc.nih.gov/.

Updates regarding government operating status and resumption of normal operations can be found at https://USA.gov/.

You are here: Home / Biomarkers / EED

EED

Basics

Aliases:
This biomarker is also known as:
  • HEED,
  • embryonic ectoderm development,
  • WAIT-1,
  • hEED,
  • WD protein associating with integrin cytoplasmic tails 1,
  • WAIT1,
  • polycomb protein EED,

Description…

EED is a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. EED is part of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. There are two known isoforms arising from two distinct transcript variants for this gene.

Attributes

QA State: Curated
Type: Protein
Short Name:
HGNC Name: EED

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Breast

Attributes

Phase: Two
QA State: Under Review

Overview

No additional breast data available.

Performance Comment

EED was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Biomuta

Mutation Statistics

Gene Name: EED
UniProt Accession #: O75530
Mutated Sites Count: 60
Associated Pubmed ID Count 8
CancerDO Count 18
Affected Protein Function Sites Count: 2

View in BioMuta