DUSP9
Basics
Aliases:
This biomarker is also known as:- MKP4,
- EC 3.1.3.16,EC 3.1.3.48,
- dual specificity protein phosphatase 9,
- dual specificity phosphatase 9,
- Mitogen-activated protein kinase phosphatase 4,
- map kinase phosphatase 4,
- serine/threonine specific protein phosphatase,
- MAP kinase phosphatase 4,
- mitogen-activated protein kinase phosphatase 4,
- MKP-4,
Description…
DUSP9 is a member of the dual specificity protein phosphatase subfamily. DUSP9 is specific for members of the ERK family of MAP kinases, is expressed only in placenta, kidney, and fetal liver, and is localized to the cytoplasm and nucleus.
Attributes
| QA State: | Curated |
|---|---|
| Type: | Protein |
| Short Name: | |
| HGNC Name: | DUSP9 |
Datasets
There are no datasets associated with this biomarker.
Organs
The following organs have data associated with this biomarker…
Breast
Attributes
| Phase: | Two |
|---|---|
| QA State: | Under Review |
Overview
No additional breast data available.
Performance Comment
DUSP9 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.
Studies
This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.
Publications
- Discovery and preliminary confirmation of novel early detection biomarkers for triple-negative breast cancer using preclinical plasma samples from the Women's Health Initiative observational study.
- Plasma biomarker profiles differ depending on breast cancer subtype but RANTES is consistently increased.
Resources
Gene
- HGNC entry for DUSP9 from Genenames
- KEGG entry for DUSP9 from Genome.jp
- Entrez entry for DUSP9 all NCBI Databasese
- Human GEO Profiles for DUSP9 from NCBI GEO Profiles
- Human Geo Datasets containing term DUSP9 from NCBI GEO Datasets
- GWAS Study Datasets containing gene DUSP9 from GWAS
- Human Single Nucleotide Polymorphisms info for DUSP9
- Human Gene(s) with 'DUSP9' as Gene Name/Alias
- Human Gene RefSeq for DUSP9 from NCBI
- GeneCards entry for human DUSP9
Protein
- UniProtKB/Swiss-Prot entry for DUSP9 from Uniprot
- Human Protein RefSeq for DUSP9 from NCBI
- FDA web page describing approval of DUSP9
Other
Biomuta
Mutation Statistics
| Gene Name: | DUSP9 |
|---|---|
| UniProt Accession #: | Q99956 |
| Mutated Sites Count: | 34 |
| Associated Pubmed ID Count | 0 |
| CancerDO Count | 15 |
| Affected Protein Function Sites Count: | 3 |
