Aliases:This biomarker is also known as:
- dickkopf homolog 3 (Xenopus laevis),
- Dickkopf-related protein 3,
- dickkopf (Xenopus laevis) homolog 3,
- regulated in glioma,
DKK3, a member of the dickkopf family, is a secreted protein containing two cysteine rich regions and involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of the DKK3 gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Highest expression in heart, brain, and spinal cord.
|QA State:||Under Review|
There are no datasets associated with this biomarker.