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This biomarker is also known as:
  • CRC18,
  • deleted in colorectal carcinoma,
  • immunoglobulin superfamily DCC subclass member 1,
  • immunoglobulin superfamily, DCC subclass, member 1,
  • Colorectal cancer suppressor,
  • colorectal tumor suppressor,
  • CRCR1,
  • netrin receptor DCC,
  • tumor suppressor protein DCC,
  • IGDCC1,
  • deleted in colorectal cancer protein,
  • Tumor suppressor protein DCC,
  • colorectal cancer suppressor,
  • Immunoglobulin superfamily DCC subclass member 1,


DCC is a receptor for netrin 1, which is required for axon guidance. DCC is a transmembrane protein and a member of the immunoglobulin superfamily of cell adhesion molecules. It mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. The cytoplasmic tail of DCC interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.


QA State: Curated
Type: Protein
Short Name:


There are no datasets associated with this biomarker.


The following organs have data associated with this biomarker…

Head & neck, NOS


Phase: One
QA State: Curated


No additional data available.

Performance Comment

DCC is one of eight genes on a panel of differentially methylated genes from normal and OSCC clinical samples from patients with heterogenous risk profiles chosen for further validation. The eight genes are: HOXA9, NID2, GATA4, KIF1A, EDNRB, MCAM, DCC, and CALCA.



Phase: Two
QA State: Under Review


Performance Comment


This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at if you should have access to this biomarker.


Mutation Statistics

Gene Name: DCC
UniProt Accession #: P43146
Mutated Sites Count: 480
Associated Pubmed ID Count 34
CancerDO Count 28
Affected Protein Function Sites Count: 3

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