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DCC

Basics

Aliases:
This biomarker is also known as:
  • Tumor suppressor protein DCC,
  • immunoglobulin superfamily, DCC subclass, member 1,
  • deleted in colorectal cancer protein,
  • Immunoglobulin superfamily DCC subclass member 1,
  • CRC18,
  • IGDCC1,
  • immunoglobulin superfamily DCC subclass member 1,
  • CRCR1,
  • Colorectal cancer suppressor,
  • tumor suppressor protein DCC,
  • deleted in colorectal carcinoma,
  • colorectal tumor suppressor,
  • colorectal cancer suppressor,
  • netrin receptor DCC,

View in BioMuta

Description…

DCC is a receptor for netrin 1, which is required for axon guidance. DCC is a transmembrane protein and a member of the immunoglobulin superfamily of cell adhesion molecules. It mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. The cytoplasmic tail of DCC interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.

Attributes

QA State: Curated
Type: Protein
Short Name:
HGNC Name: DCC

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Head & neck, NOS

Attributes

Phase: One
QA State: Curated

Overview

No additional data available.

Performance Comment

DCC is one of eight genes on a panel of differentially methylated genes from normal and OSCC clinical samples from patients with heterogenous risk profiles chosen for further validation. The eight genes are: HOXA9, NID2, GATA4, KIF1A, EDNRB, MCAM, DCC, and CALCA.

Lung

Attributes

Phase: Two
QA State: Under Review

Overview

Performance Comment

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

2015 Steering Committee Meeting

The next EDRN Steering Committee Meeting will take place March 31st through April 2nd, 2015, in Atlanta, Georgia.

Announcement 02/12/2015

Please register for the 29th EDRN Steering Committee Meeting in Atlanta, GA from March 31-April 2, 2015. The registration page has information about booking hotel rooms and a draft agenda of the meeting.

Announcement