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DCC

Basics

Aliases:
This biomarker is also known as:
  • IGDCC1,
  • Colorectal cancer suppressor,
  • CRC18,
  • deleted in colorectal cancer protein,
  • Immunoglobulin superfamily DCC subclass member 1,
  • Tumor suppressor protein DCC,
  • colorectal cancer suppressor,
  • tumor suppressor protein DCC,
  • immunoglobulin superfamily, DCC subclass, member 1,
  • deleted in colorectal carcinoma,
  • immunoglobulin superfamily DCC subclass member 1,
  • netrin receptor DCC,
  • CRCR1,
  • colorectal tumor suppressor,

Description…

DCC is a receptor for netrin 1, which is required for axon guidance. DCC is a transmembrane protein and a member of the immunoglobulin superfamily of cell adhesion molecules. It mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. The cytoplasmic tail of DCC interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.

Attributes

QA State: Curated
Type: Protein
Short Name:
HGNC Name: DCC

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Head & neck, NOS

Attributes

Phase: One
QA State: Curated

Overview

No additional data available.

Performance Comment

DCC is one of eight genes on a panel of differentially methylated genes from normal and OSCC clinical samples from patients with heterogenous risk profiles chosen for further validation. The eight genes are: HOXA9, NID2, GATA4, KIF1A, EDNRB, MCAM, DCC, and CALCA.

Lung

Attributes

Phase: Two
QA State: Under Review

Overview

Performance Comment

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Biomuta

Mutation Statistics

Gene Name: DCC
UniProt Accession #: P43146
Mutated Sites Count: 487
Associated Pubmed ID Count 38
CancerDO Count 31
Affected Protein Function Sites Count: 5

View in BioMuta