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COX7A1

Basics

Aliases:
This biomarker is also known as:
  • Cytochrome c oxidase subunit VIIa-M,
  • cytochrome c oxidase subunit VIIa-H,
  • cytochrome c oxidase subunit VIIa-heart,
  • cytochrome c oxidase subunit VIIa-M,
  • COX7AM,
  • COX7A,
  • cytochrome c oxidase subunit VIIa polypeptide 1 (muscle),
  • cytochrome c oxidase subunit VIIa heart/muscle isoform,
  • Cytochrome c oxidase subunit VIIa-H,
  • cytochrome c oxidase subunit 7A1, mitochondrial,
  • COX7AH,
  • Cytochrome c oxidase subunit VIIa-muscle,
  • Cytochrome c oxidase subunit VIIa-heart,
  • cytochrome c oxidase subunit VIIa-muscle,

Description…

COX7A1, cytochrome c oxidase subunit VIIa polypeptide 1 (muscle), is one of the polypeptide chains of cytochrome c oxidase, the terminal component of the mitochondrial respiratory chain. This polypeptide is present only in muscle tissues. Other polypeptides of subunit VIIa are present in both muscle and nonmuscle tissues, and are encoded by different genes.

Attributes

QA State: Curated
Type: Protein
Short Name:
HGNC Name: COX7A1

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Breast

Attributes

Phase: Two
QA State: Under Review

Overview

No additional breast data available.

Performance Comment

COX7A1 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Resources

External Resources for COX7A1

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 1 (muscle isoform) of subunit VIIa and the polypeptide 1 is present only in muscle tissues. Other polypeptides of subunit VIIa are present in both muscle and nonmuscle tissues, and are encoded by different genes.

Gene

Protein

Other

No other associated resources found.

Biomuta

Mutation Statistics

Gene Name: COX7A1
UniProt Accession #: P24310
Mutated Sites Count: 13
Associated Pubmed ID Count 3
CancerDO Count 9
Affected Protein Function Sites Count: 4

View in BioMuta